Mechanisms of Immune Injury (Hypersensitivity Reactions) Flashcards
1
Q
Allergy testing in vivo
A
Intracutaneous skin test or Intradermal skin test (most sensitive and gives wheal and flare rxn)
2
Q
In vitro allergy tests
A
Total IgE (Chemiluminescent assay) Allergen specific IgE
3
Q
Allergy shot mechanism
A
Decreases Th2 and increases Th1 and Treg
Means that IgG will increase while IgE will decrease
4
Q
Anaphylaxis tx
A
Try to avoid, if exposed, use epipen
If in anaphylaxis use epinephrine, IV fluids, intubate, CPR
5
Q
Coombs test
A
Direct AB test
Add anti-human globulin and anti-complement globulin to a blood sample…if aggregates, then know that there is rxn
6
Q
Direct immunofluresence
A
Can detect dz of type 2
Will show linear staining
7
Q
Membranous glomeruloneprhitis upon stainign
A
Will show granular
