Clostridia Flashcards
1
Q
Clostridia Perfringens
A
Normal in GI tract
Can cause myonecrosis.
Spores introduced to tissue…toxins destroy cells….fermentation of tissue yields gas…gas accumulates and causes crepitus
Gas gangrene
Needs dead tissue or excess nutrients to grow
2
Q
Virulence factors of clostrium perfringens
A
ASlpha toxin (lecithinase) that degrades lecithin in cell membranes
Thewta toxin lyses RBCs
Hyaluronidase and Dnase
Spores germinate in low Redox potential
3
Q
Clostridium tetani
A
Produces tetanospasmin (toxin) Tetanospasmin binds peripheral nerve terminals...transported within axon to CNS>..cleaves synaptobrevin 2
4
Q
Presentation of clostrium tetani
A
Spastic paralysis with descending pattern
5
Q
Clostrium botulinum
A
Endospore forming
Trasnmitted via home canned fruits and honey
“Floppy baby” - blocks Ach release
