Pharma2

Question 1

Pharmacokinetics

Answer 1

● The study of the disposition of a drug

● The disposition of a drug includes the processes of ADME ▪ Absorption ▪ Distribution ▪ Metabolism Elimination ▪ Excretion ▪ Toxicity

Question 2

Barbiturates on CYP450

Answer 2

Inducer & it is an sedative drug

Question 3

Enalaprilat

Answer 3

Enalaprilat, the active metabolite of enalapril, inhibits ACE. Inhibition of ACE decreases levels of angiotensin II, leading to less vasoconstriction and decreased blood pressure.
💋💋ACEI

Question 4

Tx for paracetamol overdose

Answer 4

Therefore treatment is to replace Glutathione i.e. Nacetylcysteine (Parvolex)

Question 5

Barbiturates

Answer 5

anxiolytic and sedative actions, but not used for this now

• risk of fatal overdose also dependence and tolerance

• Sometimes used as anti-epiletic drugs
Bound to the GABAa receptor

Question 6

Benzodiazepines

Answer 6

– have sedative and anxiolytic effects

– used to treat anxiety, insomnia and epilepsy
Bind to GABAa receptor

Question 7

Parkinson’s disease

Answer 7

• associated with loss of dopaminergic neurones
• substantia nigra input to corpus striatum
• can be treated with 🌸levodopa - converted to dopamine by DOPA decarboxylase

Question 8

Schizophrenia

Answer 8

• maybe due to release of too much dopamine

– amphetamine releases dopamine & noradrenaline

– produces schizophrenic like behaviour

– antipsychotic drugs are antagonists at dopamine D 2 receptors