Pharma 10 Flashcards
Myasthenia Gravis TX
It is mainly treated with acetylcholinesterase inhibitors. Whilst an acute exacerbation can cause a Myasthenic crisis, over treatment of the condition can lead to a cholinergic crisis (a flaccid paralysis and respiratory failure). Side effects of acetylcholinesterase inhibitors are 🤮🤮SSLUDGE (Salivation, Sweating, Lacrimation, Urinary incontinence, Diarrhoea, GI hypermobility, and Emesis).
PD TX
co-careldopa (Sinemet
co-beneldopa (Madopar)
L dopa ADR
yet its main disadvantages are that in long term use may show a loss of efficacy (from loss of dopaminergic neurones), causes involuntary movements, and can cause motor complications (such as “on/off”, wearing off, dyskinesia, dystonia, and freezing).
L dopa benefit
L-DOPA main advantage is that it is highly efficacious and has minimal side effects (such as N&V, hypotension, psychosis, or tachycardia)
Dopamine Receptor Agonists
Their main advantages are they are direct acting, show less motor complications, and have a possible neuroprotective role, however their 🤮🤮disadvantages are less efficacy than L-DOPA, tendency to produce impulse control disorders, expensive, and psychiatric side effects (such as sedation, hallucination, confusion, nausea, and vomiting).
DR stimulants
Ropini-role Prami-pexole Pergo-lid Caber-goline Apo-morphine
COMT inhibitor
Ooooo
Enta-capOne
Tol-capOne
MAO inhibitors
Sele-geline
Par-geline
D reuptake inhibitors
Amantidine
Anti MR Anticholinergic drugs
Orphinadrine
Benza-hexol
Benza-tropine
Pro-cyclidine
Frontal DR and limbic
Psychotic signs Hallucinations Delusion Aggression Paranoid جنون العظمة Anxiety
Pituitary DR
Hypoprolactinemia
Corpus striatum DR
Athetosis
Pallismus
Dystonia
Chorea
Medullary DR
Nausea and vomiting
Somatic SAR ئof dopamine
Hypotension and tachycardia
