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S6 > Pharma 3🧿 > Flashcards

Pharma 3🧿 Flashcards

1
Q

Hydrocortisone

A

1:1
Corticosteroids replacement
Oral

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2
Q

Prednisolone

A

4 GC:0.8
Inflammatory disease
Oral

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3
Q

Dexamethasone

A

25 GC:0
Tumor or edema
Oral

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4
Q

Betamethasone

A

25 GC:0
Topical tx
Topical

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5
Q

Fludrocortisone

A

10:125 MC
Mineralocorticoid
Replacement
Oral

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6
Q

fluticasone

A

Inhaled steroids ‡ 80% swallowed (rest stays in lungs)

‡ Lipophilic compounds retained longer in lungs

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7
Q

methylprednisolone

A

Iv

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8
Q

beclomethasone

A

Inhibitors

CG

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9
Q

flexor>

A

flexor>forehead>scalp>face>forearm

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10
Q

triamcinolone

A

Intra-articular

GC

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11
Q

depo-medrone

A

Intra articular is Methylprednisolone GC

Used for joint staff

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12
Q

Adrenal insufficiency

‡ Primary adrenal failure TX

A

‡ Hydrocortisone (10/5/5mg) ‡ Fludrocortisone (100ug) ‡ Mimic normal physiology ‡ Fludrocortisone not in pituitary diseas

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13
Q

DX of cushing syndrome

A

‡ Dexamethasone suppression test ‡ 2 days dexamethasone ‡ Measure cortisol levels before and after ‡ Normal individuals suppress < 50 nmol/l ‡ )
failure to suppress in cashing syndrome

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14
Q

Antitussives

A

butamirate.

Suppress the cough itself

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15
Q

Side effect of GC

A

‡ Osteoporosis ‡ Avascular necrosis ‡ Peptic ulcers ‡ Increased infections ‡ Hypertension ‡ Diabetes
‡ Impaired growth ‡ Skin atrophy ‡ Cataracts ‡ Corneal damage ‡ Cushingoid features

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16
Q

Cushingoid features

A

‡ Rounded face ‡ Plethoric features ‡ Acne ‡ Poor wound healing ‡ Central obesity ‡ Proximal myopathy
‡ Buffalo hump ‡ Thin skin ‡ Easy bruising ‡ Abdominal striae ‡ Hypertension ‡ Diabetes mellitus

17
Q

Steroid sparing agent

A

‡ Reduced steroid requirement ‡ Azathioprine ‡ 🌸Cyclophosphamide ‡ Biological therapies ‡ Important for reducing steroid side effects

18
Q

Synthetic estrogen analogs

A

ethinyl-estradiol,
m-estranol
and estradiol valerate,
analogs have a prolonged action and a higher potency compared to those of natural estrogens.

19
Q

Progesterone derivatives

A

Medroxy-progesterone,
Dyhdro-gesterone,
deso-gestrel,
etono-gestrel .

20
Q

Testosterone derivatives

A 
Nore-thiste-rone, 
Nore-thindr-one , 
nor-gest-rel, 
Nor-gest-imate
Testosterone Enenthate,
 Pro-prionate Undecanoate, Mesterolone
21
Q

Implant co

A

Eto-no-rgestrel
اتو نو جستيشن
It is an pro-gesterone
Last for 3 y

22
Q

Progestogens: which generation?

A

1: nore-thyno-drel
2 nd : levo-norgestrel, nore-thister-one
3 rd : des-ogestrel, gesto-dene, nor-ges-timate
4 th : dros-pire-none (Yasmin),
norel-gestro-min (Evra: patch)

23
Q

Raloxifene

A

Protects against osteoporosis ƒ No proliferative effects on endometrium ƒ No proliferative affect breast ƒ 🤮🤮🤮Increases hot flushes ƒincreased risk of DVT, pulmonary embolism, & retinal vein thrombosis
SERM☺️

24
Q

Clomiphene

A

ovulation induction: inhibit oestrogen binding anterior pituitary, inhibit negative feedback, results in increased GnRH and FSH, LH .Side effects : hot flushes, ovarian enlargement & risk of multiple pregnancy

25
Q

Tamoxifen

A

used for treatment of metastatic breast cancer, or as adjuvant therapy following mastectomy or radiation for breast cancer , and as prophylactic therapy to reduce the risk of breast cancer in high-risk patients.

26
Q

Ospemifene

A

is indicated for the treatment of dyspareunia (painful sexual intercourse)

related to menopause.

27
Q

Mife-pristone

Midwife 😁

A

progesterone antagonist inhibits progesterone action ƒ Sensitises the uterus to prostaglandins

ƒ Used for medical termination of pregnancy with 🤷🏻‍♀️miso-prostol, and induction of labour

28
Q

Cypro-terone

A

Anti androgen
ƒWeak progestogenic effect. Partial agonist to progesterone receptor, competes with dihydrotestosterone ƒUsed in combined contraceptive pill (Dianette)

29
Q

Fina-steride

A

👾👾inhibit 5α-reductase resulting in decreased formation of dihydrotestosterone. used for the treatment of 👉🏿👉🏿benign prostatic hyperplasia .
Selective

30
Q

Flu-tamide

A

👾👾act as competitive inhibitor of androgens at the target cell and are effective orally for the treatment of 👉🏿👉🏿prostate cancer .

S6 (21 decks)

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