Pharma Flashcards
Which mechanism explains aspirin’s inhibition of thromboxane synthesis? (A) Blocks cyclooxygenase (B) Blocks lipoxygenase (C) Blocks phospholipase A 2 (D) Blocks PGE 1 receptors (E) Blocks PGI 2 receptors
A
A 57-year-old man has severe pulmonary hypertension
and right ventricular hypertrophy. Which of the following
agents causes vasodilation and may be useful in pulmonary
hypertension?
(A) Acetylcholine
(B) Bradykinin
(C) Prostaglandin PGF 2α
(D) Prostacyclin
(E) Thromboxane
D
A 19-year-old woman complains of severe dysmenorrhea. A uterine stimulant derived from membrane lipid in the endo- metrium is (A) Angiotensin II (B) Oxytocin (C) Prostacyclin (PGI 2 ) (D) Prostaglandin PGF 2α (E) Serotonin
D
The inducible isoform of nitric oxide synthase (iNOS,
isoform 2) is found primarily in which of the following?
(A) Adipose tissue
(B) Eosinophils
(C) Macrophages
(D) Platelets
(E) Vascular endothelial cells
C
The primary endogenous substrate for the enzyme nitric oxide synthase (NOS) is (A) Acetylcholine (B) Angiotensinogen (C) Arginine (D) Citrulline (E) Heme
C
A 60-year-old financial consultant presents with severe pain
in a neuronal dermatome region of her chest. This area
was previously affected by a herpes zoster rash. Which of
the following might be of benefit in controlling this post-
herpetic pain?
D
Which of the following is an antagonist at NK 1 receptors and is used to prevent or reduce chemotherapy-induced nausea and vomiting? (A) Angiotensin I (B) Aprepitant (C) Bosentan (D) Bradykinin (E) Brain natriuretic peptide (F) Enalapril (G) Ondansetron
B
Which of the following is an antagonist at NK 1 receptors and is used to prevent or reduce chemotherapy-induced nausea and vomiting? (A) Angiotensin I (B) Aprepitant (C) Bosentan (D) Bradykinin (E) Brain natriuretic peptide (F) Enalapril (G) Ondansetron
C
A laboratory study of new H 2 blockers is planned. Which of
the following will result from blockade of H 2 receptors?
(A) Increased cAMP (cyclic adenosine monophosphate)
in cardiac muscle
(B) Decreased channel opening in enteric nerves
(C) Decreased cAMP in gastric mucosa
(D) Increased IP 3 (inositol trisphosphate) in platelets
(E) Increased IP 3 in smooth muscle
C
