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Atilim Y2 Immunology > Final > Flashcards

Final Flashcards

1
Q

Induces thrombocyr aggregation

A

TxA2

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2
Q

Doesn’t have vasodilatory

A

Leukotriene c4

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3
Q

Cause of increased vessel permeability in burns

A

Direct endothelial injury

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4
Q

Not a chemotactic agent

A

Histamine

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5
Q

Inflammation in diptheria

A

Pseudomembraneous

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6
Q

Not an acute inf

A

Granulomatous inf

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7
Q

L selectin fount in

A

WBC

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8
Q

E selectin found in

A

Endothelial

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9
Q

P selectin found in

A

Platelets

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10
Q

Tnf induces

A

Inflammation

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11
Q

Il 1 induces

A

Fever

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12
Q

Chemokines il8, MIP

A

Attract neutrophils and macrophages

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13
Q

Il6 induces

A

Acute phase proteins

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14
Q

C5a

A

Attract neutrophils

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15
Q

Cause of pain in inf

A

Low ph

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16
Q

Splenectomy diseases bacteria example

A

S pneumonia
Neisseria meningitis
Hawkophilus influenzae

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17
Q

Antibody meditated neutralization is done on exotoxins like

A

Corynebacterium, clostridium tetani

Clostridium botulinum

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18
Q

Cause of redness in inf

A

Histamine

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19
Q

Histamine is …. immunity

A

Innate

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20
Q

MHC class 2 is what cells

A

Dendritic
B cell
Macrophages

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21
Q

Nk cells participate in ADCC but they don’t

A

Initiate antigen presentation

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22
Q

Bacteria mucosal surface immunoglobulin

A

IgA

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23
Q

MHC function

A

Binds peptide antigen and presents to T cell

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24
Q

This t cell helps isotype switching and antibody production

A

Tfh cell

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25
Q

IFN Gamma is not acossiated with

A

Plasma cell formation and antibody production

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26
Q

This cytokine inhibits the immune response

A

Il 10

Ifn beta

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27
Q

Initial step in antibody is binding of antigen to b cell surface via

A

Bcr

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28
Q

Cytokine attracts neutrophils and inhibit bacteria

A

Il8

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29
Q

Antibody crosses placenta

A

IGg

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30
Q

This test detects num and type of immune cells in peripheral blood

A

Flow cytometry

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31
Q

PD 1 and CTLA 4 are targets for immune therapy and are bothe expressed on

A

Activated t cell

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32
Q

These cytokines attract neutrophils

A

Il8, il 17

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33
Q

Ige meduated histamine is what hypersensitivity reaction

A

Type 1

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34
Q

Which cell expresses receptors fro IgE on its cell and respond to worns

A

Mast cell

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35
Q

Laboratory assays considered to be invitro counterparts

A

IFN gamma treated with TB antigen

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36
Q

During second trimester of pregnancy

A

Liver

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37
Q

Where does affinity of hemoglobin increase

A

Hemoglobin f

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38
Q

Called as sinusoids, have large perforations, highly discontinous basement membrane

A

Discontinued cappillaries

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39
Q

Origin of heart tube

A

Splanchnic mesoderm

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40
Q

Doesn’t originate from the first phrngeal arch

A

Stapes

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41
Q

Disease associated with thymomas

A

Myasthenia gravis

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42
Q

Precursor lesion of squamous cell carcinoma

A

Squamous dystplasia

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43
Q

Patient who encounters tuberculosis bacillus for the first time

A

Supressed immunity

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44
Q

Which is non hodgkin lymphoma

A

Extranodal marginal zone

45
Q

Nk produces ….. to stimulate macrophages

A

Inf gamma

46
Q

Cd 4 releases a cytokine, its function is

A

Macrophages distraction of phagocytes microbes

47
Q

Immunosuppressive cytokine

A

Il 10

48
Q

This TLR. Recognizes lipopolysaccharite structure in outer membrane of gram negative bacteria (endotoxins)

A

TLR 4

49
Q

Lassa fever

A

Occurs from contact of rodents

50
Q

Anaphylatoxins

A

C3a, C4a

51
Q

Secrets antibodies

A

Plasma cells

52
Q

Causing agrnt of community acquired atypical pneumonia

A

Mycoplasma pneumonia

53
Q

Transplant between different species

A

Xenografts

54
Q

Pollen provikes which type of hypersensitivity

A

Type 1

55
Q

Hypersensitivity thats t cell mediated

A

Type 4

56
Q

Binds to mast cells, cause degranulation, release histamine

A

IgE

57
Q

Type o blood lacks

A

Antigens

58
Q

Type 2 hyper sensitivity cause

A

Mismatch blood type

59
Q

Positive tuberculin tesr means

A

Delayed hypersensitivity

60
Q

Tissue graft between not identical PEOPLE

A

Alloegraft

61
Q

Examples of type 3 immune complex disease

A

Serum sickness

62
Q

Graft when the recipient lacks immune system and the donor organ express different

A

hla

63
Q

Agammmagloubinemia is deficiency in

A

B cells

64
Q

Similar to aidS

A

SCID

65
Q

Hiv high mutation because

A

Reverse transcriptase

66
Q

Pregnancy test detects the presence if

A

Human chorionic gonadotropin

67
Q

Autoimmune disease

A

Rheumatoid arthritis

68
Q

Breastfeeding goves what type of immunity

A

Passive acqured

69
Q

Molecules that increase ANC count (nutrophil)

A

Granulocyte CSF

70
Q

A baby starts vaccination, his t cells are naive, t cells are dependent on which of the following molecular interactions

A

Binding of CD28 to B7-1 (CD80)

71
Q

Pro inf cytokines

A

IL1, il6, TNF alpha

72
Q

MALT

A

Dimeric ig with secretory components

73
Q

Allergeb is

A

Molecule that bonds to antibody sensitizing the surface of mast cells

74
Q

Primary immunodeficiency producing susceptibility to infections by viruses snd molds is caused by

A

T cell deficiency

75
Q

Stess induced by excercise increases susceptibility to infection by

A

Raising plasma levels of cortisol

76
Q

Produced by th2 CD cells wgich provide help for antobody production but not Th1 cells

A

IL4

77
Q

Immunological memory can he transferred by

A

Lymphocytes

78
Q

Statement about interferons

A

Induce enzyme synthesis in the target cells

79
Q

Neutrophils defensibs are

A

Peptide antibiotics

80
Q

Neutrophils contain

A

Microbicidial cytoplasmic granules

81
Q

Which of the following doesn’t protect body surface

A

Salivary amilase

82
Q

PRR includes which of the following

A

PAMPS

83
Q

This cytokine promotes allergic response and inhibit cell mediated

A

IL 4

84
Q

Signal transduction through TCR is enhanced by

A

CD 28

85
Q

Oral vaccine

A

Mucosal IgA sectetion

86
Q

What is activated by B7 expressed by B cells

A

CD 4 cell

87
Q

What amels rheumatoid arthritis and endo toxic shock

A

TNF

88
Q

After receiving flu shit by a month a man gets influenza, ehat cell prevents pneumonia

A

Memory lymphocyte

89
Q

Not true about regulatory T cell

A

Control immune responses by lysing effector CD 4 T cells

90
Q

IgE mediated histamine

A

Type 1

91
Q

Naive T cells encounter antigen and start their activation where

A

Lymph node para cortex

92
Q

Low ig G and memory b cells is impairment of

A

Th2 effector T cells

93
Q

Il2 produced by

A

T cells

94
Q

Il23 produced by

A

Macrophages and dendritic

95
Q

Interaction of pathogen molecule with TLR directly results in

A

Cell activaton and production of cytokines and chemokines

96
Q

Nk cells recognizes

A

MHC class 1 molecules

97
Q

Antigen- antibidy conplexes are phagocytosed in the presence of

A

C3b

98
Q

Primary lymphoid organ

A

Thymus

99
Q

Statement about major histo compatibility is false

A

Surface proteins found in every cell

100
Q

Lymph from lymph nodes with afferent lymphatic vessels enters first in

A

Subcapsullary sinus

101
Q

Which structure is located between splinic sinusoids mainly composed of macrophages

A

Billroth cords

102
Q

Prearteriolar lymphatic sheath in observed in

A

Spleen white pulp

103
Q

This cell makes up hassal corpuscles

A

Epithelial reticular cells

104
Q

The lymph fluid comes to lymph nodes passes which region first

A

Subcapsular sinus

105
Q

Which lymphoid organ normally develops less functionality and high adipose with age

A

Thumus

106
Q

The iron occurs most actively in

A

Spleen

107
Q

Partly encapsulated and covered by non keratinized stratified squamous epithelium

A

Palatine tonsils

108
Q

Thymic corpuscles (hassal) are composed of

A

Thpe VI reticular cells

109
Q

In which organ medulla and hassal onserved in medulla

A

Thymus

Atilim Y2 Immunology (10 decks)

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