Final Flashcards
Induces thrombocyr aggregation
TxA2
Doesn’t have vasodilatory
Leukotriene c4
Cause of increased vessel permeability in burns
Direct endothelial injury
Not a chemotactic agent
Histamine
Inflammation in diptheria
Pseudomembraneous
Not an acute inf
Granulomatous inf
L selectin fount in
WBC
E selectin found in
Endothelial
P selectin found in
Platelets
Tnf induces
Inflammation
Il 1 induces
Fever
Chemokines il8, MIP
Attract neutrophils and macrophages
Il6 induces
Acute phase proteins
C5a
Attract neutrophils
Cause of pain in inf
Low ph
Splenectomy diseases bacteria example
S pneumonia
Neisseria meningitis
Hawkophilus influenzae
Antibody meditated neutralization is done on exotoxins like
Corynebacterium, clostridium tetani
Clostridium botulinum
Cause of redness in inf
Histamine
Histamine is …. immunity
Innate
MHC class 2 is what cells
Dendritic
B cell
Macrophages
Nk cells participate in ADCC but they don’t
Initiate antigen presentation
Bacteria mucosal surface immunoglobulin
IgA
MHC function
Binds peptide antigen and presents to T cell
This t cell helps isotype switching and antibody production
Tfh cell
IFN Gamma is not acossiated with
Plasma cell formation and antibody production
This cytokine inhibits the immune response
Il 10
Ifn beta
Initial step in antibody is binding of antigen to b cell surface via
Bcr
Cytokine attracts neutrophils and inhibit bacteria
Il8
Antibody crosses placenta
IGg
This test detects num and type of immune cells in peripheral blood
Flow cytometry
PD 1 and CTLA 4 are targets for immune therapy and are bothe expressed on
Activated t cell
These cytokines attract neutrophils
Il8, il 17
Ige meduated histamine is what hypersensitivity reaction
Type 1
Which cell expresses receptors fro IgE on its cell and respond to worns
Mast cell
Laboratory assays considered to be invitro counterparts
IFN gamma treated with TB antigen
During second trimester of pregnancy
Liver
Where does affinity of hemoglobin increase
Hemoglobin f
Called as sinusoids, have large perforations, highly discontinous basement membrane
Discontinued cappillaries
Origin of heart tube
Splanchnic mesoderm
Doesn’t originate from the first phrngeal arch
Stapes
Disease associated with thymomas
Myasthenia gravis
Precursor lesion of squamous cell carcinoma
Squamous dystplasia
Patient who encounters tuberculosis bacillus for the first time
Supressed immunity
Which is non hodgkin lymphoma
Extranodal marginal zone
Nk produces ….. to stimulate macrophages
Inf gamma
Cd 4 releases a cytokine, its function is
Macrophages distraction of phagocytes microbes
Immunosuppressive cytokine
Il 10
This TLR. Recognizes lipopolysaccharite structure in outer membrane of gram negative bacteria (endotoxins)
TLR 4
Lassa fever
Occurs from contact of rodents
Anaphylatoxins
C3a, C4a
Secrets antibodies
Plasma cells
Causing agrnt of community acquired atypical pneumonia
Mycoplasma pneumonia
Transplant between different species
Xenografts
Pollen provikes which type of hypersensitivity
Type 1
Hypersensitivity thats t cell mediated
Type 4
Binds to mast cells, cause degranulation, release histamine
IgE
Type o blood lacks
Antigens
Type 2 hyper sensitivity cause
Mismatch blood type
Positive tuberculin tesr means
Delayed hypersensitivity
Tissue graft between not identical PEOPLE
Alloegraft
Examples of type 3 immune complex disease
Serum sickness
Graft when the recipient lacks immune system and the donor organ express different
hla
Agammmagloubinemia is deficiency in
B cells
Similar to aidS
SCID
Hiv high mutation because
Reverse transcriptase
Pregnancy test detects the presence if
Human chorionic gonadotropin
Autoimmune disease
Rheumatoid arthritis
Breastfeeding goves what type of immunity
Passive acqured
Molecules that increase ANC count (nutrophil)
Granulocyte CSF
A baby starts vaccination, his t cells are naive, t cells are dependent on which of the following molecular interactions
Binding of CD28 to B7-1 (CD80)
Pro inf cytokines
IL1, il6, TNF alpha
MALT
Dimeric ig with secretory components
Allergeb is
Molecule that bonds to antibody sensitizing the surface of mast cells
Primary immunodeficiency producing susceptibility to infections by viruses snd molds is caused by
T cell deficiency
Stess induced by excercise increases susceptibility to infection by
Raising plasma levels of cortisol
Produced by th2 CD cells wgich provide help for antobody production but not Th1 cells
IL4
Immunological memory can he transferred by
Lymphocytes
Statement about interferons
Induce enzyme synthesis in the target cells
Neutrophils defensibs are
Peptide antibiotics
Neutrophils contain
Microbicidial cytoplasmic granules
Which of the following doesn’t protect body surface
Salivary amilase
PRR includes which of the following
PAMPS
This cytokine promotes allergic response and inhibit cell mediated
IL 4
Signal transduction through TCR is enhanced by
CD 28
Oral vaccine
Mucosal IgA sectetion
What is activated by B7 expressed by B cells
CD 4 cell
What amels rheumatoid arthritis and endo toxic shock
TNF
After receiving flu shit by a month a man gets influenza, ehat cell prevents pneumonia
Memory lymphocyte
Not true about regulatory T cell
Control immune responses by lysing effector CD 4 T cells
IgE mediated histamine
Type 1
Naive T cells encounter antigen and start their activation where
Lymph node para cortex
Low ig G and memory b cells is impairment of
Th2 effector T cells
Il2 produced by
T cells
Il23 produced by
Macrophages and dendritic
Interaction of pathogen molecule with TLR directly results in
Cell activaton and production of cytokines and chemokines
Nk cells recognizes
MHC class 1 molecules
Antigen- antibidy conplexes are phagocytosed in the presence of
C3b
Primary lymphoid organ
Thymus
Statement about major histo compatibility is false
Surface proteins found in every cell
Lymph from lymph nodes with afferent lymphatic vessels enters first in
Subcapsullary sinus
Which structure is located between splinic sinusoids mainly composed of macrophages
Billroth cords
Prearteriolar lymphatic sheath in observed in
Spleen white pulp
This cell makes up hassal corpuscles
Epithelial reticular cells
The lymph fluid comes to lymph nodes passes which region first
Subcapsular sinus
Which lymphoid organ normally develops less functionality and high adipose with age
Thumus
The iron occurs most actively in
Spleen
Partly encapsulated and covered by non keratinized stratified squamous epithelium
Palatine tonsils
Thymic corpuscles (hassal) are composed of
Thpe VI reticular cells
In which organ medulla and hassal onserved in medulla
Thymus
