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MedBoardsPrep > Pharma > Flashcards

Pharma Flashcards

0
Q

Movement of drug molecules within biologic membranes

A

Permeation

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1
Q

Water & Lipid solubility of Weak Acid & Base

A

WATER SOL

  • weak acid: unprotonated
  • weak base: protonated

LIPID SOL

  • weak acid: protonated
  • weak base: unprotonated
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2
Q

Zero Order Elimination

50% every half life

A 
'WHAT PET'
Warfarin
Heparin
Aspirin
Tolbutamide
Phenytoin
Ethanol
Theophylline
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3
Q

Diminished response after drug administration

Drugs?

A

Tachyphylaxis

*'MED Love CNN HD'
Metoclopromide
Ephedrine
Dobutamine
LSD
Calcitonin
Nitroglycerine
Nicotine
Hydralazine
Desmopressin
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4
Q

Amout / fraction of srug administered that reaches systemic circulation

A

Bioavailability

*determined by AREA UNDER THE CURVE

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5
Q

Standard in vitro test for Mutagenicity

A

AMES Test

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6
Q

Sjogren Syndrome?
Sicca Syndrome?

Drug?

A

Sjogren (triad)

  • Sicca syndrome: xeroatomia & xerophthalmia
  • RA

Mx: Pilocarpine (M3R activator)

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7
Q

Ogilvie Syndrome

Drug mx?

A

Neostogmine
-AchE inhibitor

*Acute Colonic Pseudo Obstruction

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8
Q

Indirect acting Cholinomimetic

(AchE inhibitor) used in Alzeimer’s

A

Rivastigmine

*SimDrx: Galantamine Donepezil Tacrine

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9
Q

Anti-Muscatinic used in Parkinson’s

A

Benzteopine
(anti-M; restores NT balance in Basal Ganglia)

*SimDrx: Biperiden. Trihexyhenidyl

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10
Q

Cholinergic Antag (Anti-M) used in Motion sickness

A

Scopolamine

blocks ALL M receptors; antag to Histamine & Serotonin

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11
Q

Dose Dependent Actions of Dopamine

A

1-5mcg/kg/min : D1 vasodil splanchnic & renal vasculature
5-10mcg/kg/min : B inc renal BF, HR, cardiac contractility, CO
10-15mcg/kg/min: £ vasoconstriction, inc BP

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12
Q

Mx of Rebound HPN secondary to Clonidine overdose

A

Phentolamine

Non selective £ Antag : £1>£2

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13
Q

Drx used for Presurgical Pheochronocytoma

A

Phenoxybenzamine
(Non Selective £ Antag : £1>£2)

*covalent bond formation - long half life)

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14
Q

Drug induced Lupus

A 
'HIPP'
Hydralazine
INH
Procainamide
Penicillamine
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15
Q

SE: Gingival Hyperplasia

A

Verapamil - non-dihydropyr CCB
Nifedipine - dihydropyr CCB
Cyclosporine - NSAID (-)IL
Phenytoin

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16
Q

Mx of Class 1A Antiarrhythmia

A

Na-Lactate

*‘I Am the Queen who Proclaimed Diso Pyramid’
Class IA - Quinidine Procainamide Disopuramide

17
Q

PGF2£ analog used in Galucoma but may cause permanent eye color change

A

Latanoprost

*Carboprost - PGF2£ analog used as abortifacient & to ctrl post partum hemox

18
Q

Triad of Hemochromatosis

A

Cirrhosis
DM
Skin pigmentation

19
Q

Organophosphate toxicity

A

Atropine - anti-M
Pralidoxime - AchE regenerator

*admin within 4-6hrs

20
Q

Performance ehnhancing drug used by athletes

A

Epoetin £
-EPO R agonist

*SimDrxs: Methoxy polyethelene, DarbePOETIN £, Glycon-POETIN B

21
Q

Recombinant form of endogenous cytokine w/c activates IL-11 Rs

A

Oprelvekin
(Megakaryocyte GF)

*SimDrx: Thrombopoietin

22
Q

SAMSTER TRIAD

A 
ASA Hypersensitivity
'ANA'
ASA sensitivity
Nasal polyps
Asthma
23
Q

Anti-Plt used during PCI to prevent restenosis

A

Abxicimab
(anti-gpIIb-IIIa binding to Fibrinogen)

*SimDrxs: Tirofiban Eptifibatide

24
Q

DOC for Pulmonary HPN

A

Epoprostenol

PGI2 analog

25
Q

Omalizumab
Abciximab
Infliximab
Adalimumab

A

Omalizumab - anti-IgE in BA
Abciximab, Cilostazol (Pletal) - Phosphodiesterase III inhib - antiplt
Infliximab, Adalimumab, Etanercept - DMARD binds to TNF£ ^

^ causes REACTIVATIONS of TB HepB, AutoAb formation, Lymphoma

26
Q

Corneal deposits

A

Amiodarone

  • cornea & skin
  • Class III with Class IA antiarrythmic effect

Chloroquine

  • nightmares
  • Anti-Malaria; DMARD T Lympho response suppression
27
Q

Date-Rape drugs

A

Alcohol - MC
Gamma Hydroxybutyrate
Flunitrazepam
-long acting Benzodiazepine

  • SimDrxs: Diazepam Flurazepam Quazepam CHLORazepate CHLORdiazepoxide (longest t1/2 36-200hrs)
  • short acting: MidaZOLAM TriaZOLAM Oxazepam
  • int acting: LoraZEPAM ClonaZEPAM Alprazolam
28
Q

For pxs with Sleep disorders

A

‘Zzzz’
Zolpidem
Zaleplon
Eszopiclone

38
Q

Trigeminal Neuralgia DOC

A

Carbamazepine

- TCA AntiSeizure

39
Q

Cytochrome P450 Inhibitors

A 
'SICKER V GAQ'
Sulfonamides
INH
Cimetidine
Ketoconazole
Erythromycin
Ritonavir
Valproic Acid
Grapefruit Juice
Amiodarone
Quinidine
40
Q

Cytochrome P450 Inducer

A 
'BERP C GSS'
Barbiturates
Ethanol
Rifampicin
Phenytoin
Carbamazepine
Griseofulvin
Smoking
St Worts
41
Q

Pseudomembranous colitis

A

‘CAC’

Clindamycin
Ampicillin
Cephalosporins (3rd gen)

42
Q

Post-Herpetic neuralgia

Allodynia

A

Gabapentin

  • GABA derivative anticonvulsant
  • inhib Ca channels; inc GABA release

*SimDrx: Pregabalin

43
Q

AntiSeizure contraindicated in Schiz pxs due to Psychosis adverse effect

A

Leviteracetam

  • Piracetan anyiconvulsant
  • sel binds Synaptic Vesicle Protein SV2A
  • modifies glutamate & GABA release
44
Q

Anticonvulsant for Lennox Gastaut & West Syndrome

A

Topiramate

  • monosaccharide derivative
  • most number of MOA & toxicities (myopia galycoma urolithiasis memory impairment)
45
Q

Sz of diff types
Psych & behavioral abn
Dev delay

A

Lennox-Gastaut Syndrome

46
Q

Infantile Spasm
Dev regress
EEG: Hipp’s Arrythmia -pathog

A

West Syndrome

*Infantile spasm - Clonazepam

47
Q

Reversal agt for Rocuronium

A

Sugammadex

48
Q

Used for pxs with Strichnine posoning

For Lethal inj Euthanasia

A

Pancuronium

  • Non-dep skel muscle relaxant
  • competitive antag at SkM NICOTINIC Ach R
  • moderate block of CARDIAC MUSCARINIC Ach R

MedBoardsPrep (17 decks)

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