Others Flashcards
Carcinogenic omponents in cigarette smoking
Polycyclic aromatic hydrocarbon
Tar
Benzopyrene
Nitrosamine
Only protective mehanism aainst Mercury poisoning
Intracellular Glutathione
Gastric Ulcer and Squamous Cell CA ulcer as a complication of burn injury
Gastric - Curling Ulcer
Squamous Cell CA - Marjolin ulcer (overturned burn edges)
Keshan Disease
Selenium deficiency
aka Endemic Cardiomyopathy
Acrodermatitis enterooathica
Zinc deficiency
Normal capillary pressure
Venous 12mmHg
Capillary 20mmHg
Arteriole 32mmHg
To prevent Seroma formation in a graft
Mesh
MC site of Necrotizing Tissue Infection
Perineum
Ext genitalia
Abdominal wall
Definitve managemnt of Necrotizing Tissue Infection
Debridement
Granulomatous suppuratice bacterial infection. Present as nodules forming draining tracts following tooth odontogenic procedures.
Actinomycosis
+ sulfur granules
Necrotic lesions, rapidly enlarging. ‘harbringer of Bad Nees’
Associated (50%) with underlying disease
Pyoderma gangrenosum
Congenital nevi with ‘swimming trunk’ distribution
Haiy Cell Nevi
MC soft tissue tumor
Lipoma
Type of Basal Cell CA that metastasizes distally
Basosquamous BCC
-mimics SCCA mets
MC type of basal Cell CA
Nodulocystic
Noduloulcerative
SCCA type om the neck, hands, face of elderly
Lentigo Maligna
- best prognosis
Trendelenburg sign
Gluteus medius - weak thigh abduction
‘waddling gait’
Main supinator of the arm
Biceps brachii
Musculocutaneous N
Main flexor of the arm
Brachialis
Musculocutaneous N
Rotator cuff muscles
'SITS' Supraspinatus -Abductor (Suprascap N) Infraspinatus - lat rotator (") Teres minor - " (Axillary N) Subscapularis - " (Upper subscap N)
Abductors - supraspinatus and deltoid (Axillary N)
Major blood supply to the femoral head
Medial femoral circumflex
*Obturator artery supplies only a small branch to the femoral head
Triceps surae
Gastrocnemius and Soleus
(forms Achille’s tendon)
*posterior Leg Compartment
Superficial grp - Triceps surae, plantatris
Deep grp - politeus, FDL, FHL, Tibialis posterior
Can’t stand on TIP TOES
Tibial Nerve Injury
(Plantarflexion)
*Tibial N gives rise to Plantar (Lat &Medial) Nerves which supplies the sole of the foot
‘Steppage gait’
Common Peroneal Nerve Injury
(FOOT DROP - loss of dorsiflexion)
*Raise leg high then foot slaps to the floor when walking
Triad of O Donoghue
ACL
MCL
Medial Meniscus
- Ant Drawer - forward slide of TIBIA on flexion due to ACL rupture (LAX on FLEX)
- Post Drawer - backward slide of TIBIA on extension due to PCL rupture (LAX on EXTENSION)
First bone to undergo ossiication
Clavicle
Contents of Carpal tunnel
Flexor Digi Superficialis tendon
Flexor Digi Profundus tendon
Flexor Pollicis Longus tendon
Median Nerve
‘FDS FDP FPL MN’
* formed by Flexor retinaculum (volar carpal lig + transverse carpal lig)
Modulates cold sensation
Krausse’s end bulb
Modulates sensitivity to warmth - Ruffini’s endings
Modulates pressure sensation - Paccinian corpuscles
Modulates tactile sensation- Meissner’s corpuscles
Modulates thermoregulation - Auonomic endings
Plummet Vinson Syndrome
IDA
Cervical Dysphagia
Atrophic oral mucosa( TongueCA)
Brittle spoon finger nails
Sarcomere parts thatshortens during contraction
H & I bands
*A band does not shorten
Muscle proteins Dystropin Desmin Capz Titin
Dystrophin - attaches to plasmalemma
Desmin - Z line to plasma mem
Capz & Actinin - Actin to Z line
Titin - Myosin to Z line (bind M & Z)
Proprioceptors
Muscle spindles
- parallel pattern
- Muscle LENGTH
- RATE of change in Muscle Length
Golgi Tendon
- series pattern
- Muscle TENSION
Glycolipid Storage Diseases Tay-Sach's Disease Farber's Disease Fabry's Disease Krabbe's Disease Gaucher's Disease Niemann-Pick
Tay-Sach's - Hexosaminidase def Farber's -Ceramidase def Fabry's - £ Galactosidase def Krabbe's - B Galactosidase def Gaucher's - B Glucosidase def Niemann-Pick - Sphingonyelinase def
Lipiprotein Diseases Type1 Familial Lipoprotein Lipase Type2 Familial Hypercholeterolinemia Type3 Familial Dysbetalipoproteinemia Abetalipoproteinemia Familial £ Lipoproteinemia Def
Type1 Lipoprotein Lipase def
Type2 Hypercholeterolinemia - LDL receptor def
Type3 Dysbetalipoproteinemia - Apo E def
Abetalipoproteinemia - Apo B100 & Apo B48 def
£ Lipoproteinemia - Apo I-A def
(Tangier’s Disease & Fisheye Disease)
Amino acid used to determine Folic Acid Deficiency
Histamine
(N-ForIminoGlutamate Excretion Test)
- high doses of Histamine ingestion causes increase excretion of FIGlu in urine of Folic Acud deficient pxs
Only Non-CHIRAL Amino Acid
Only Amino Acid that has an IMINO group
Non-Chiral - Glycine
Imino group - Proline
Menke’s Disease
Copper deficiency
*required by LYSYL OXIDASE, the key step in Covalent X-link formation to strengthen Collagens
Mucopolysaccharide Diseases
Hunter’s
Hurler’s
Morquio’s
Hunter’s - Iduronate sulfatase def
Hurler’s - £ Iduronidase def
Morquio’s - Galactose 6 sulfatase def
*Morquio-no CNS abn
Total purine = Total pyrimidine
Chargaff’s Rule
Vit B
B1-Thiamine B2 - Riboflavin B3 - Niacin B5 - Pantothenic acid B6 - Pyrodoxine B7 - Biotin B9 - Folc Acid B12 - Cobalamin