Pharm practice questions

Question 1

contraception for a smoker with CAD: (goserelin/mifepristone/mestranol and norgestrel/medroxyprogesterone)

Answer 1

medroxyprogesterone (intramuscular injection every three months)

Question 2

combination therapy contraception: (goserelin/mifepristone/mestranol and norgestrel/medroxyprogesterone)

Answer 2

mestranol and norgestrel (not for smokers!)

Question 3

long-lasting GnRH analog used for suppression of gonadotropin secretion in cases of precocious puberty and “medical castration” in pedophiles: (goserelin/mifepristone/mestranol and norgestrel/medroxyprogesterone)

Answer 3

goserelin

Question 4

long term use can lead to vaginal dryness and bone loss: (goserelin/mifepristone/mestranol and norgestrel/medroxyprogesterone)

Answer 4

goserelin

Question 5

used for early abortion: (goserelin/mifepristone/mestranol and norgestrel/medroxyprogesterone)

Answer 5

mifepristone

Question 6

an antiestrogen that blocks estrogen binding to its receptors in the hypothalamus, inhibiting estradiol’s negative feedback on gonadotropins

Answer 6

clomiphene

Question 7

antiestrogen that stimulates proliferation of the uterine endometrium, increasing the risk of uterine cancer

Answer 7

tamoxifen

Question 8

micronized (estrogen/progesterone) is contraindicated in those with HTN, pregnancy, risk for breast cancer, and is compounded with peanut oil in micronized form

Answer 8

progesterone (so don’t give it to people with peanut allergies)

Question 9

(combination pills/progesterone only pills): less effective, acceptable for lactating women and those with hx of venous thrombosis

Answer 9

mini pills (progesterone only)

Question 10

progestin (suppresses/stimulates) secretion of LH

Answer 10

suppresses (prevents ovulation)

Question 11

progestin (reduces secretion of/thickens) cervical mucus

Answer 11

thickens

Question 12

codeine is metabolized by cyp (2C19/2D6)

Answer 12

cyp2D6 (prodrug metabolized by cyp2D6 to morphine)

Question 13

etanercept mechanism of action: (inhibition of IL-1 receptor/reduction of circulating active TNF alpha levels)

Answer 13

reduction of TNF alpha levels. Etanercept is a soluble TNF reCEPTor that will bind up circulating active TNF alpha

Question 14

_____ soluble IL-1 receptor antagonist

Answer 14

anakinra

Question 15

_____ inhibits T cell proliferation and B cell autoantibody production

Answer 15

lefunomide

Question 16

______ selectively inhibit COX-2

Answer 16

newer NSAIDs

Question 17

_____ most effective treatment for acute gouty arthritis

Answer 17

colchicine (prevents release of inflammatory cytokines and chemotactic factors)

Question 18

_____ blocks renal uric acid reabsorption but is generally not used alone during the acute phase of gout

Answer 18

probenecid

Question 19

______ drug of choice in chronic tophaceous gout

Answer 19

allopurinol

Question 20

indomethacin drug class

Answer 20

NSAID

Question 21

there is a drug-drug interaction between _____ and azathioprine (whose active metabolite is 6-MP)

Answer 21

allopurinol. 6-MP is broken down by xanthine oxidase (which is inhibited by allopurinol)

Question 22

drug-drug interaction of allopurinol and azathioprine leads to what presentation

Answer 22

bone marrow suppression (potentially fatal)

Question 23

notable for lack of serious side effects: (aurothioglucose/hydroxycholoquine/
azathioprine/cyclosporine)

Answer 23

hydroxychloroquine