Pharm- Platelet inhibitors

Question 1

Ticlopidine- Indications

Answer 1

Prevention of TIA, strokes for patient with previous events, with aspirin to prevent thrombus

Question 2

Ticlopidine- MOA

Answer 2

Block platelet aggregation by inhibiting binding of ADP to receptors- prevent platelets from binding to fibrinogen and each other

Question 3

Ticlopidine- AE

Answer 3

hematologic, thrombocytic purpura, aplastic anemia, neutropenia

Question 4

Clopidrel- Indications

Answer 4

Prevention of artherosclerotic events following MI, stroke, peripheral artery disease, prevention of thrombotic events

Question 5

Clopidrel- MOA

Answer 5

Block platelet aggregation by inhibiting binding of ADP to receptors- prevent platelets from binding to fibrinogen and each other

Question 6

Clopidrel- AE

Answer 6

thrombotic throbocytopenic purpura, poor metabolizers,

Question 7

Aspirin- Indications

Answer 7

Prophylaxis of ischemia, MI. Prevention of clotting

Question 8

Aspirin- MOA

Answer 8

Irreversibly inhibits COX 1- reduces prostaglandin, and thrombaoxane. Reduces platelet aggregation

Question 9

Aspirin- AE

Answer 9

Increased bleeding time, GI bleeds