Coagulation Disorders Flashcards
Vit. K Deficiency- Eti
Malabsorption, nutrition, decreased production due to chemo or abx
Vit. K Deficiency- Sx
Reduced coagulation, decreased clotting factors with normal factor V
Vit. K Deficiency- Dx
Prolonged prothrombin time, low levels of clotting factors
Vit. K Deficiency- Tx
Oral Vit K
Disseminated Intravascular Coagulation- Eti
Uncontrolled locoal or systemic activation of coagulation- depletion of coagulation factor & fibrinogen- assoc with sepsis, cx, trauma, burns
Disseminated Intravascular Coagulation- Sx
Bleeding at multiple sides, widespread purpura fulminates
Disseminated Intravascular Coagulation- Dx
Acute & progressive prolongation of coagulation studies- PT & PTT, throbocytopenia,
Disseminated Intravascular Coagulation- Tx
Tx underlying disorder, platelet infusion therapy, achieve homeostasis
Coagulopathy of liver disease- Eti
Impaired hepatic function due to cirrhosis or other liver disorders- decreased synthesis of clotting factors & fibrinogen
Coagulopathy of liver disease- Sx
Prolonged PT, corrects with mixing normal plasma. Bleeding disorder
Coagulopathy of liver disease- Dx
Deficiencies in fibrinogen, clotting factors
Coagulopathy of liver disease- Tx
Fresh, frozen plasma if bleeding complications occur
Aplastic anemia- Eti
Autoimmune, idiopathic anemia, bone marrow failure due to suppression or injury of hematopoietic stem cells- pancytopenia
Aplastic anemia- Sx
Weakness, fatigue, vulnerability to bacterial or fungal infections, mucosal & skin bleeding, pallor, purpura and petechiae. No hepatosplenomegaly, lymphadenopathy or bone tenderness
Aplastic anemia- Dx
Hypocellular BMB, pancytopenia, severe anemia, unremarkable RBC morphology
