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BCP 1 > Pharm- anticoagulants > Flashcards

Pharm- anticoagulants Flashcards

1
Q

Heparin- Indications

A

Prevention of DVTs, treatment of PEs, pregnancy

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2
Q

Heparin- MOA

A

Binds to antithrombin III, inactivates coagulation factors

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3
Q

Heparin- AE

A

hemorrhage, thrombocytopenia, hypersensativity

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4
Q

Heparin- Monitoring

A

Bleeding time

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5
Q

LMWH- Indications

A

Prophylaxis of DVT, MI,

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6
Q

LMWH- MOA

A

Selectively accelerates interaction of antithrombin with factor Xa

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7
Q

LMWH- AE

A

Fewer than heparin, less frequent bleeding,

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8
Q

Fondaparinux- Indications

A

Prophylaxis of DVT, acute PE & DVT in combination with warfarin.

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9
Q

Fondaparinux- MOA

A

Selectivly inhibits factor Xa by selectivly binding to antithrombin III

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10
Q

Fondaparinux- AE

A

Bleeding, no throbocytopenia

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11
Q

Warfarin- Indications

A

Prevention of progression or recurrence of DVT or PE following initial heparin tx. Prophylaxis of MI, a-fib

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12
Q

Warfarin- MOA

A

Antoagonize cofactor function of Vit. K

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13
Q

Warfarin- AE

A

Black box for bleeding, pregnancy, drug-drug interactions

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14
Q

Warfarin- Monitoring

A

INR regularly to adjust dose

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15
Q

Dabigatran- Indications

A

Prevention of stroke, embolism, a-fib. Does not require INR

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16
Q

Dabigatran- MOA

A

Direct thrombin inhibitor

17
Q

Dabigatran- AE

A

Bleeding, GI, fewer drug-drug interactions than warfarin

18
Q

Rivaroxaban- Indications

A

Prophylaxis of DVT, stroke, PE

19
Q

Rivaroxaban- MOA

A

Selective inhibition of factor Xa

20
Q

Rivaroxaban- AE

A

Risk of thrombosis with discontinuation, Bleeding, epidural/ spinal hematoma, back pain

21
Q

Apixaban- Indications

A

Prophylaxis of DVT, stroke,

22
Q

Apixaban- MOA

A

Selectively inhibits factor Xa

23
Q

Apixaban- AE

A

Risk of thrombosis with discontinuation, Bleeding, epidural/ spinal hematoma, anemia

BCP 1 (13 decks)

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