Hypercoaguable States Flashcards
Factor V Leiden- Eti
Common in caucasians. Hereitable disorder- leiden variant in factor V resulting in increased clotting. Inability of protein C to inactivate
Factor V Leiden- Sx
Excessive clotting, superficial and deep DVTs, PEs less common. Exacerbated by estrogen, pregnancy.
Antiphospholipid antibody syndrome- Eti
Autoab mediated thrombophilia. Assoc with SLE, scleroderma, sjogrens, RA
Antiphospholipid antibody syndrome-Sx
Arterial or venous thrombotic event, multiple pregnancy loss
Antiphospholipid antibody syndrome- DX
Immunoassasys for antiphospholipid Abs.
Antiphospholipid antibody syndrome- Tx
Lifelong warfarin, INR monitoring
Protein C deficiency- Eti
Heritable disorder causing loss of function of protein C- increased clotting
Protein C deficiency- Sx
Purpura fulminans in newborns (coagulation in small vessels leading to necrosis), increased clot formation leading to thrombotic events
Protein C deficiency- Dx
Immunologic assay
Protein C deficiency– Tx
Warfarin
Homocystinemia- Eti
Genetic disorder leading to abnormal methionine metabolism- elevated homocystine in blood.
Protein S deficiency- Eti
Rare heterogenous genetic disorder. Low or abnormal function of protein S- unregulated coagulation. Can also be acquired due to low Vit K
Protein S deficiency- Sx
Increased risk of DVT, PE, stroke, purport fulmains in adults
Protein S deficiency- Tx
Warfarin
Homocytinemia-Eti
Autosomal recessive deficiency of cytathionine Beta synthase. Extreme elevation of plasma and urinary homocysteine
