Pharm-One Liners

Question 1

A class of endogenous substances that include histamine, serotonin, prostaglandins, and vasoactive peptides that work in autocrine or paracrine manner

Answer 1

Autacoids

Question 2

Two peptide that increase capillary permeability and edema

Answer 2

Bradykinin and histamine

Question 3

Distribution of histamine receptors H1, H2, and H3

Answer 3

Smooth muscle and mast cells; stomach, heart, and mast cells; nerve endings, CNS respectively

Question 4

Most common side effect of 1st generation antihistamines

Answer 4

Sedation, anticholinergic

Question 5

1st generation antihistamine that is highly sedating

Answer 5

Diphendydramine

Question 6

1st generation antihistamine that is least sedating

Answer 6

Chlorpheniramine

Question 7

Major indication for H1 antihistamines

Answer 7

IgE mediated allergic reaction (allergic rhinitis, urticaria)

Question 8

Antihistamine that is indicated for allergies, motion sickness, and insomnia

Answer 8

Diphenhydramine

Question 9

Antihistamine with motion sickness as the only indication

Answer 9

Dimenhydrinate

Question 10

Three 2nd generation antihistamines

Answer 10

Fexofenadine, loratadine, and cetirizine

Question 11

H2 antagonist that causes the most interactions with other drugs

Answer 11

Cimetidine

Question 12

Indication for H2 antagonists

Answer 12

Acid reflux disease, duodenal ulcer and peptic ulcer disease

Question 13

Mechanism of action of cromolyn

Answer 13

Prevent mast cell degranulation (by blocking opening of Cl- channels)

Question 14

Enzyme which theophylline inhibits

Answer 14

Phosphodiesterase