Obstructive Lung Disease

Question 1

Decrease in FEV1/FVC ratio

Answer 1

Obstructive Lung Diseases

Question 2

Hyperplasia of mucus-secreting glands in the bronchi; Reid Index >50%

Answer 2

Chronic Bronchitis

Question 3

Productive cough for >3months per year for >2years

Answer 3

Chronic Bronchitis

Question 4

Destruction of alveolar walls

Answer 4

Emphysema

Question 5

Blue bloater

Answer 5

Chronic bronchitis

Question 6

Pink Puffer

Answer 6

Emphysema

Question 7

Centriacinar emphysema

Answer 7

Associated with smoking; primarily upper lungs

Question 8

Panacinar emphysema

Answer 8

Associated with alpha1-antitrypsin defiency (primarily in lower lobes, and may have associated liver cirrhosis)

Question 9

Exhalation through pursed lips

Answer 9

Emphysema

Question 10

PiM

Answer 10

normal allele for alpha1-antitrypsin

Question 11

PiZ

Answer 11

most common mutation for alpha1-antitrypsin (if homozygous; panacinar emphysema with cirrhosis)

Question 12

Charcot Leyden crystals

Answer 12

breakdown of eosinophils; asthma

Question 13

Curschmann spirals

Answer 13

epithelium mucus plugs; asthma

Question 14

Methacholine Challenge

Answer 14

Tests for asthma

Question 15

Th2 secretes

Answer 15

IL4(plasma to IgE); IL5(eosinophils); IL10(inhibit Th1)

Question 16

Chronic necrotizing infection of bronchi > permanently dilated airways; foul smelling sputum

Answer 16

Bronchiectasis

Question 17

Diseases associated with Bronchiectasis

Answer 17

Kartagener, CF, Allergic Bronchopulmonary, Aspergillosis