PHARM NSAIDS.GOUT

Question 1

MOA of NSAIDS

Answer 1

inhibit prostaglandin synthesis by inhibiting cyclo-oxygenase (cox)

Question 2

Difference between aspirin and other NSAIDS

Answer 2

Aspirin irreversibly inhibits cyclooxygenase

Question 3

Four main actions of NSAIDS

Answer 3

Anti-inflammatory, analgesia, antipyretic and antiplatelet activity

Question 4

Agent used for closure of patent ductus arteriosus

Answer 4

Indomethacin

Question 5

The reason why aspirin is contraindicated in children with viral infection

Answer 5

Potential for development of Reye’s syndrome

Question 6

SE of salicylates

Answer 6

Tinnitus, GI bleeding

Question 7

NSAID available orally, IM, IV, nasally, and ophthalmically

Answer 7

Ketoralac

Question 8

NSAID that is used for acute condition, such as pre-op anesthesia and has limited duration (<5 days) of use due to nephrotoxicity

Answer 8

Ketoralac

Question 9

Newer NSAIDs that selectively inhibit COX-2

Answer 9

Celecoxib

Question 10

COX 2 inhibitors may have reduced risk of

Answer 10

Gastric ulcers and GI Bleeding

Question 11

COX 2 inhibitors should be used cautiously in pts with

Answer 11

Pre-existing cardiac or renal disease

Question 12

Acetaminophen only has what activity?

Answer 12

Antipyretic and analgesic activity

Question 13

SE of acetaminophen

Answer 13

Hepatotoxicity

Question 14

Antidote for acetaminophen toxicity

Answer 14

N-acetylcysteine

Question 15

DMARDs are slow acting drugs for

Answer 15

Rheumatic disease

Question 16

MOA of gold salts

Answer 16

Alter activity of macrophages and suppress phagocytic activity of PMNs

Question 17

SE of gold salts

Answer 17

Dermatitis of the mouth aplastic anemia and agranulocytosis

Question 18

Causes bone marrow suppression

Answer 18

Methotrexate

Question 19

SE of penicillamine

Answer 19

Aplastic anemia and renal

Question 20

Interferes with activity of T-lymphocytes

Answer 20

Hydroxychloroquine

Question 21

Anti-malarial drug used in rheumatoid arthritis (RA)

Answer 21

Hydroxychloroquine

Question 22

SE of hydroxychloroquine

Answer 22

Retinal destruction and dermatitis

Question 23

MOA of Leflunomide (newer agent)

Answer 23

Inhibiting Dihydroorotate Dehydrogenase which leads to decreased pyrimidine synthesis

Question 24

Proteins that prevent action of tumor necrosis factor alpha (TNF-alpha)

Answer 24

Infliximab and etanercept

Question 25

Anti-rheumatic agent also used for ulcerative colitis

Answer 25

Sulfasalazine

Question 26

NSAID used in gout

Answer 26

Indomethacin, ibuprofen

Question 27

NSAID avoided in gout because low doses increases uric acid levels

Answer 27

Aspirin

Question 28

MOA of Colchicine (used in acute gout)

Answer 28

Selective inhibitor of microtubule assembly

Question 29

SE of colchicine

Answer 29

Kidney and liver toxicity, diarrhea, myelosuppression

Question 30

Agent used to treat chronic gout by increasing uric acid excretion through inhibition of URAT1 anion transporter

Answer 30

Probenecid

Question 31

Agent that inhibits xanthine oxidases and used to treat chronic gout

Answer 31

Allopurinol, febuxostat

Question 32

Recombinant uricases that enhance uric acid metabolism

Answer 32

rasburicase, pegloticase