BLOCKERS

Question 1

Nonselective alpha-blocking drug, long acting and irreversible, and used to treat pheochromocytoma. Blocks 5-HT, so occasionaly used for carcinoid tumor. Blocks H1 and used in mastocytosis

Answer 1

Phenoxybenzamine

Question 2

Nonselective alpha-blocking drug, short acting and reversible, used for rebound HTN from rapid clonidine withdrawal, and Raynaud’s phenomena

Answer 2

Phentolamine

Question 3

Selective Alpha 1 blocker used for hypertension, BPH, may cause first dose orthostatic hypotension

Answer 3

Prazosin, terazosin, doxazosin

Question 4

Selective Alpha 2 blocker used for impotence (controversial effectiveness)

Answer 4

Yohimbine

Question 5

Selective B1 Receptor blockers that may be useful in treating cardiac conditions in patients with asthma

Answer 5

Acebutolol, atenolol, esmolol, metoprolol

Question 6

Combined alpha and beta blocking agents that may have application in treatment of CHF

Answer 6

Labetalol and carvedilol

Question 7

Beta blockers partial agonist activity (intrinsic sympathomimetic activity) cause some bronchodilation and may have an advantage in treating patients with asthma

Answer 7

Pindolol and acebutolol

Question 8

This beta blocker lacks local anesthetic activity (decreases protective reflexes and increases the risk of corneal ulceration) and used in treating glaucoma

Answer 8

Timolol

Question 9

This parenteral beta blocker is a short acting

Answer 9

Esmolol

Question 10

This beta blocker is the longest acting

Answer 10

Nadolol

Question 11

These beta blockers are less lipid soluble

Answer 11

Acebutolol and atenolol

Question 12

This beta blocker is highly lipid soluble and may account for side effects such as nightmares

Answer 12

Propranolol

Question 13

Clinical uses of these agents include treatment of HTN, angina, arrhythmias, and chronic CHF

Answer 13

Beta blockers

Question 14

Toxicity of these agents include bradycardia, AV blockade, exacerbation of acute CHF, signs of hypoglycemia may be masked (tachycardia, tremor, and anxiety)

Answer 14

Beta blockers

Question 15

Cholinomimetics that increase outflow, open trabecular meshwork, and cause ciliary muscle contraction

Answer 15

Pilocarpine, carbachol, physostigmine

Question 16

Nonselective alpha agonists that decrease aqueous production and increase aqueous outflow

Answer 16

Epinephrine, dipivefrin

Question 17

Selective alpha agonists that decreases aqueous secretion

Answer 17

Apraclonidine, brimonidine

Question 18

These Beta blockers decrease aqueous secretion

Answer 18

Timolol (nonselective), betaxolol (selective)

Question 19

This diuretic decreases aqueous secretion due to lack of HCO3- ion. Causes drowsiness and paresthesias, alkalinization of the urine may precipitate calcium salts, hypokalemia, acidosis

Answer 19

Acetazolamide

Question 20

This agent cause increased aqueous outflow

Answer 20

Prostaglandin PGF2a (latanoprost, travoprost, unoprostone)