Pharm Exam 4 Flashcards
1
Q
- Uti Treatment x5
- Super infection
- Gram Negative Drugs x1
- Gram Positive Drugs x2
A
- Bactrim, Amoxicillin, Fluroquinolones, Macrodantoin, Pyridium (BAFMyPee)
- Broad Spectrum, infection on top of earlier infection, THRUSH, Vag YEAST
- Aminoglycoside
- Antitubercular
2
Q
- Bacteriostatic
- Bacteriocidal
- Drugs that contain -static and -cidal x3
- ototoxcity drugs x3
A
- inhibits growth, lower dose
- kills, higher dose
- penicillin, macrolides, lincosamides
- Vanomycin, Amphoteracin, Gentamycin
3
Q
- -vir
- -mine
- -zine
- -mycin
- exception to mycin
A
- antivirals
- 1st generation antihistamine
- 2nd generation antihistamine
- lincosamide
- aminoglycoside, know gentamycin
4
Q
- Liver Toxicity
- Renal Toxicity
- Creatnine BUN
A
- Ketoconazole, RTI, Protease, INH, Tetracycline, Macrodantin
- Amphoteracin HIGH, Gentamycin, Acyclovir, Tetra, Vanomycin
- Peptides, acycloir, gentamycin
5
Q
- GI upset
- Peripharl Neruopathy
- This is not an antibiotic
- Narrow Spectrum drug
A
- Fluroquinolones Ampicillin, , MAcrodantoin, Erythromycin famous gi upset!
- INH
- Pyridium
- Aminoglycoside
6
Q
- Take with food
- Empty stomache
- Food or no food
A
- erythromycin, flagyl, macrodantoin (efoom)
- penicillin, INH, Tetra (pit, hole)
- ampicillin- watch CITRUS
7
Q
- First generation antihistamine
- 2nd generation antihistamine
- SE of Oral antihistamine
- Most effective antiasthma drug
A
- Sedating
- Non-sedating
- anticholinergic- dry mouth, constipation, urinary retention
- glucocorticoids
8
Q
- Long term, prophylaxis Asthma prevention x3
- Side effects of glucocorticoid inhaler
- Why do you rinse your mouth with glucocorticoid inhaler?
- Used with glucocorticoid inhaler?
- Cromolyn
A
- Glucocorticoid inhaler, Long Acting inhaled Beta 2 agonist, Comolyn
- throat, dry mouth, cough
- oral fungal infections
- Long acting Beta 2 Agonist
- Mast cell wall stabilixer, prevents mediators
9
Q
- Acute Asthma treatment
- SE of oral glucocorticoids
- How can you take Selective Beta 2 Receptor?
- Categories for Beta 2 Agonist/Bronchodilator Agents
A
- Oral glucocorticoids, Selective Beta 2 Receptor, Short Acting inhaled Beta 2
- peptic ulcer, T.E., must taper
- nebulizer, inhaler, systemic effects w/ oral
- methyxanthines, anticholinergics
10
Q
- What part does asthma effect?
- Types of antiinfammatory agents
- What does cromolyn do?
- What is a leukotriene
- Singulair
A
- Lower respiratory tract
- Glucocorticoids, cromolyn, leukotriene modifiers, IgE antagonist
- Stabilize Mast Cell Wall
- chemical mediator for inflammatory response
- Leukotriene antagonist, bronchodilation
11
Q
- Asthma.Methylxanthin derivative agents
- Methylxanthin agents cause…
- Theophylline OFF market
- Theophylline action
- How do you give it?
A
- Aminophylline, Theophyline, Caffeine
- bronchodilation, CNS excitation, Vasodilation, Cardiac stimulus, diuresis
- Too many SE, narrow window,
- relaxes smooth muscle of bronchi
- IV or oral
12
Q
- Aminophyline
- Anticholinergic for Asthma (COPD off Label)
- Action
- SE of Ephedrine
- SE of Pseudoephedrine
A
- Salt Theophylline, give slow–>hypotension/death. incompatible
- Atrovent(inhaled), Tiotropium
- Bronchodilator
- HTN, Dysrrythmias, MI, Stroke, Seizure, hyperglycemia, OFF MARKET
- Cardiovasscular collapse, HTN, Seizure
13
Q
- Antitussive, Upper Respiratory Tract, cough
- Dextromethorphan
- Diphenydramine
- Non drowsy, antihistamine for hay fever
A
- Relief of non productive cough, medulla, drowsiness
- Non-narcotic, OTC, cold remedy
- also a antihistamine, help to sleep, allergy, cold, cough
- Fexofenadine/Allegra
14
Q
Allergic Rhinitis, MAST CELL
- Histamines
- Leukotrines
- Prostaglandins
A
- vasodilate, itching, mucus, inc cap perm, bronchoconstrict
- asthma, bronchoconstrict, mucus, airway, edema
- vasodilate, fever, PAIN, inc cap permeability
15
Q
- Glucocorticoids and allergies
- First line thearpy for allergic rhinitis
- What else cane you use to treat allergy?
- Antihistamine prophylaxxis allergy treatment
A
- dec inflam, inhibit prostaglandin relese, INTRANASAL MOST effective
- intransal glucs, oran/intranasal antihis
- sympathomimetics
- Histamine 1, common, sneeze, rhinorrhea, itchy nose. DOESN NOT REDUCE NASAL CONGEST
16
Q
- Decongestants stimulate which recptor?
- Action
- Phenylphine, Oxymetazoline, Sudafed Usage, Sympathomimetics
- Respiratory and Obstructive Complications
A
- Alpha 1 Receptor
- HTN, Constrict NOSE
- use for 5 days only, rebound congestions
- beta 2 adrenergic agonist
17
Q
- How C/S test can decrease resistance
- misues of antibiotics what percent?
- Vanomycin
- Side effects of Vanomycin
- Prevention for antibiotic use
A
- Actual microbe specific to antibiotic
- 50% use in hospital that don’t need them
- Effective against MRSA (avoid use), GLYCOPEPTIDE
- redman syndrome, slow iv or pump
- vaccines, limit catheters, c/s before, handwashing
18
Q
- Gen Broad spectrum antibiotics
- Penicillin Action
- Most common type of penicillin
- Allergy alternative to Penicillin
- Macrolide
A
- Thromycin
- Beta lactam, interfere with cell wall, LYSE
- Amoxicillin, low resp infection, skin infection,
- Erythromyciin (Macrolide)
- supress protein synthesis, bacteriostatic
19
Q
- Antibacterial Categories
- How do you treat allergic reactions?
- Gram+
- Gram -
- Mycostatin
A
- Penicillins, cephlosporins, macrolides, lincosamides, sulfonamides, glycopeptides, aminoglycoside, tetra, fluroquinolones, antTB, antifungal
- antihistamins, bronchoDILATORS, ephinephrine
- thick wall, purple (cocci)
- thin wall, violet, neisseria
- antifungal, candidiasis, leakage membrane
20
Q
- Lincosamides,
- Resemblence to Penicillin
- Penicillin resistance
- Penicillin patient education
- Cephalosporin
A
- inhibit protein synthesis, SE colitis, rash, antiacne
- cephalosporin
- Staph, MRSA, Methicillin (NOMARKET)
- reduce contraceptive, take entirety, stomatitis, vaginits, c/s before
- most common, less side effects, broad spectrum
21
Q
- Tetracycline uses
- Adverse effects
- Why vitamin b6 and inh
- Flagyl action
- Alcoholic effects of flagyl
A
- Chlamydia, anthrax, cholera, lyme, ulcer, acne, pneumonia, rm spotted fever
- photo, discolr teeth, NO <8yrs, dec effective of BC pills
- decrease peripheral neuropathy
- Impairs DNA function of bacteria, antibiotica, antiprotozoal
- causes disulifiram, for alcoholics
22
Q
- Flagyl Use
- Colorectal surgery
- Adverse effects
- Gentamycin what will you watch for?
- Administer Gentamycin how
A
- GI, GI, CNS, C.DIFF, antiulcer, antiinefect, antiprotozoal
- flagyl, prophylaxis
- dark urine,
- narrow window, urin output, balance, hearing
- IM IV
23
Q
- Potent antibiotic
- Adverse effects
- Decrease risk of crystalluria
- What is fluroquinolones good for?
A
- Fluroquinolones, not 1st line treatment
- photo, gi, crystalluria
- increse fluid intake
- tissue penetration, respiratory tract infection, inhibit DNA synthesis.
24
Q
- Antiseptic, antiinfective
- Baceter…
- Adverse Effect
- Pyridium and urine
A
- **Macrodantin **UTI’s
- cidal, static
- peripheral neruopathy,dizzy, drowsy RUSTY URINE
- analgesic w/ antibiotic discolors urine. NOT ANTIMICROBIAL, take when symptoms are gone
25
Q
- Sulfanomides
- What do sulfanomides treat
- Silvadene
- Action of sulf
A
- Bactrim, Septra, bronchitis too
- UTI-E.coli, otitis media, newborn eye prophylaxis
- Topical, for burns
- interefers with folic acid synthesis, -static
26
Q
- Amphotericin B category
- administration
- Action of amph B
- Drug of choice for ringworm, alternative to ampho
A
- polyene, antifungal, RENAL, severe (mening in HIV patients)
- IV only
- binds to membrane allow leakage
- ketoconazole
27
Q
- This is an antiretroviral agent used to treat HIV
- HAART
- Cocktail for HAART
- How long for use
- Adverse Effects
A
- AZT
- Highly Active Antiretrioviral Therapy
- 2 Rti’s with Protease inhibitor
- lifetime
- drug interaction, anemia neutropenia, anorexia,liver, lactic acidosis
28
Q
HAART
- Action
- Safety
- Assess
A
- undetectable viral lode, improves CD4 count
- does not prevent trasnmission, need refular follow up exams
- hypersenstivity
29
Q
Neurominidase inhibitors
- What does it treat
- when should you take it
- How does it treat?
A
- release of virus from infected cells
- within 48 hours of flu symptoms
- Inhibits the enzyme, may alter virus Particle
30
Q
- Antiviral, Antiherpes
- Route
- action
- Treats
- Adverse effects
A
- acyclovir,
- Topical, oral IV (oral prevents recurrence)
- varicella zoster, EBV, herpes
- gingival hyperplasia, encourage fluids, renal BUN
31
Q
- AntiTB bacteria
- How is it transmitted
- Cell wall
- How long for treatment
- Approach
A
- Acid Fast Bacillus (rods)
- droplet
- Thick, resitat to penetration by antiinfectives
- 6-24 months
- Use combo drugs
32
Q
- What is Isoniazide
- Action
- Route
- Labs
- SE
A
- prophylaxis antiTB
- inhibts mycobacterial cell wall synthesis and intereferes with metabolism
- First oral drug affective against TB
- Liver enzymes, Sputum samples morning
- Peripheral neuropathy b6
33
Q
1. Expectorants drugs
- Define Expectorant
- Has both Adrenergic and Corticosteroid
A
- Robitussin,
- Liquefy secretions, increases respiratory tract fluid
- Symbicort, Advair