Pharm Exam 3 (Hypothalamic)

Question 1

Vasopressin Antagonists

Answer 1

(-vaptan)

Tolvaptan — W/ HF & SIADH
Conivaptan — W/O HF, Osmotic Demyelination (ADR)

Question 2

Growth Hormone Receptor Antagonist (1)

Answer 2

Pegvisomant — Acromegaly

Question 3

Gonadotropin Receptor Antagoinst (3)

Suppress LH & FSH

Answer 3

(-Elix)

Ganirelix — Controlled ovarian Hyperstimulation procedures
Cetrorelix — Controlled ovarian Hypestimulation procedures
Degarelix — Advanced Prostate Cancer

Question 4

FSH/LH Agents

Answer 4

Follitropin alfa (rFSH)
Follitropin beta (rFSH)
Urofollitropin (UFSH)

Ovulation induction/Male infertility

Question 5

Dopamine Antagoinst (1)

Answer 5

Metoclopramide — N/V, Stimulation of lactation in women (off-label)

Question 6

Dopamine Agonists (2)

Answer 6

Bromocriptine — Multiple, DM

Cabergolide — Multiple

Question 7

P Pituitary agents (3)

Answer 7

Oxytocin — Simulate labor, control postpartum bleeding
Vasopressin (ADH) — Esophageal Varices, Vasodilatory shock
Desmopressin — DI, Primary Noctunal enuresis, Temporary Polyuria & Polydipsia

Question 8

A Pit Agents (8)

Answer 8

Somatotropin
Somatrem
Octreotide
Lanreotide
Cosyntropin
Leuprolide
Nafarelin
Goserelin

Question 9

Treat GH deficient growth failure

Answer 9

Soamatropin

Somatrem

Question 10

Treat Acromegaly

Answer 10

Octreotide & Lanreotide (Somatostatin)

Pegvisomant (GHRA)

Question 11

Somatostatin (2)

Answer 11

(-tide)

Octreotide — Acromegaly, Bleeding esophageal Varices, VIP secreting tumors
Lanreotide — Acromegaly

Question 12

Treat Esophageal Varices (2)

Answer 12

Octreotide (somatostatin)

Vasopressin (ADH)

Question 13

Diagnostic agents (2)

Answer 13

Cosyntropin
Corticotropin

(ACTH)

Question 14

Synthetic Analog of GnRH (3)

Answer 14

Leuprolide, Nafarelin, Goserelin (-elin)

Question 15

HYPERsecretory Disease (3)

Answer 15

Acromegaly, Gigantism, HYPERprolactinemia

Question 16

HYPOsecretory Disease

Answer 16

GH Deficiency, Panhypopituitarism