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Step 1 Review > Pharm > Flashcards

Pharm Flashcards

1
Q

Aminoglycosides

A 
"GNATS"
Gentamicin
Neomycin
Amikacin
Tobramycin
Streptomycin
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2
Q

Aminoglycosides - Adverse effects

A

NEPHROTOXICITY
Neuromuscular blockade (NO in MG)
OTOTOXICITY (specially with loop diuretics)
Teratogenicity

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3
Q

Aminoglycosides - Mechanism of resistance

A

Bacterial transferase enzymes inactivate the drug by acetylation, phosphorylation or adenylation.

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4
Q

Aminoglycosides - Mechanism of action

A

Bactericidal

Irreversible inhibition of initiation complex by binding of the 30S subunit.

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5
Q

Inducers

A 
MOdafinil
CHRONIC ALCOHOL use
St. John Wort
PHENytoin
PHENobarbital
NEvirapine
Rifampin
GRIseofulvin
CARBamazepine
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6
Q

Inhibitors

A 
Sodium valproate
Isoniazid
Cimetidine
Ketoconazole
Fluconazole
Acute alcohol use
Chloramphenicol
Erythromycin/Clarythromycin
Sulfonamides
Ciprofloxacin
Omeprazole
Metronidazole
Amiodarone
Ritonavir
Grapefruit Juice

SICKFACES.COM

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7
Q

Substrates

A

Anti-epileptics
Theophyline
Warfarin
OCP’s

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Step 1 Review (14 decks)

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