Oncogenes & Tumor supressor genes Flashcards
Oncogenes
1-hit gain of function (1 allele)
Tumor supressor genes
2-hit loss of function (2 alleles)
Lynch Syndrome
MSH2
MLH1
Lung AdenoCa
ALK - Receptor tyrosine kinase
ONCO
CML
ALL
BCR-ABL - Non receptor TK
ONCO
Follicular and Diffuse Large B cell lymphoma
BCL-2 - Antiapoptotic
ONCO
Melanoma
Non-Hodgkin Lymphoma
Papillary thyroid Ca
Hairy cell Leukemia
BRAF - Serine/threonine kinase
ONCO
GI stromal tumor (GIST)
c-KIT - Cytokine receptor (Stem cell GF)
ONCO
Burkitt Lymphoma
c-MYC - transcription factor (nuclear regulator)
t(8;14)
(ONCO)
Breast and Gastric Ca
HER2/neu (c-erb82) - Receptor tyrosine kinase (epidermal growth factor receptor)
(ONCO)
Chronic myeloproliferative disorders
JAK2 - Tyrosine kinase
ONCO
Colon Ca
Lung Ca
Pancreatic Ca
KRAS - GTPase binding protein (point mutation)
ONCO
Lung Tumor
L-myc - transcription factor
ONCO
Neuroblastoma
N-myc -transcription factor
ONCO
MEN 2A
MEN 2B
Papillary thyroid Ca
Pheochromocytoma
RET - receptor TK
ONCO
Colorectal Ca (associated to FAP)
APC - Negative regulator of ß-catenin/WNT pathway
TSG
Breast Ca
Ovarian Ca
Pancreatic Ca
BRCA1/BRCA2 - proteins
TSG
Melanoma
Pancreatic Ca
CDKN2A - p16, blocks G1 –> S phase
TSG
Colon Ca
DCC - Deleted in colon cancer
TSG
Pancreatic Ca
SMAD4 (DPC4) - Deleted in pancreatin Ca
TSG
MEN1
Menin
TSG
Neurofibromatosis type 1
NF1 - Neurofibromin (Ras GTPase activating protein)
TSG
Neurofibromatosis type 2
NF2 - Merlin (schwannomin) protein
TSG
Prostate Ca
Breast Ca
Endometrial Ca
PTEN - Negative regulator of PI3k/AKT pathway
TSG
Retinoblastoma
Osteosarcoma
Rb - Inhibits E2F; Blocks G1 –> S phase
TSG
Most human Ca
Li-fraumeni Syndrome
SBLA Ca Syndrome: Sarcoma, Breast, Leukemia, Adrenal gland
TP53 - activates has p21; blocks G1 –> S phase
TSG
Tuberous sclerosis
TSC1 - Hamartin protein
TSC2- Tuberin protein
(TSG)
von-Hippel-Lindau
VHL - inhibits hypoxia-inducible factor 1a
TSG
Wilms Tumor
WT1 - Urogenital development transcription factor
TSG
Lynch Syndrome can cause?
Colon Ca
Endometrial Ca
Ovarian Ca
Skin Ca