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Oncogenes & Tumor supressor genes Flashcards

1
Q

Oncogenes

A

1-hit gain of function (1 allele)

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2
Q

Tumor supressor genes

A

2-hit loss of function (2 alleles)

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3
Q

Lynch Syndrome

A

MSH2

MLH1

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4
Q

Lung AdenoCa

A

ALK - Receptor tyrosine kinase

ONCO

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5
Q

CML

ALL

A

BCR-ABL - Non receptor TK

ONCO

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6
Q

Follicular and Diffuse Large B cell lymphoma

A

BCL-2 - Antiapoptotic

ONCO

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7
Q

Melanoma
Non-Hodgkin Lymphoma
Papillary thyroid Ca
Hairy cell Leukemia

A

BRAF - Serine/threonine kinase

ONCO

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8
Q

GI stromal tumor (GIST)

A

c-KIT - Cytokine receptor (Stem cell GF)

ONCO

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9
Q

Burkitt Lymphoma

A

c-MYC - transcription factor (nuclear regulator)
t(8;14)
(ONCO)

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10
Q

Breast and Gastric Ca

A

HER2/neu (c-erb82) - Receptor tyrosine kinase (epidermal growth factor receptor)
(ONCO)

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11
Q

Chronic myeloproliferative disorders

A

JAK2 - Tyrosine kinase

ONCO

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12
Q

Colon Ca
Lung Ca
Pancreatic Ca

A

KRAS - GTPase binding protein (point mutation)

ONCO

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13
Q

Lung Tumor

A

L-myc - transcription factor

ONCO

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14
Q

Neuroblastoma

A

N-myc -transcription factor

ONCO

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15
Q

MEN 2A
MEN 2B
Papillary thyroid Ca
Pheochromocytoma

A

RET - receptor TK

ONCO

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16
Q

Colorectal Ca (associated to FAP)

A

APC - Negative regulator of ß-catenin/WNT pathway

TSG

17
Q

Breast Ca
Ovarian Ca
Pancreatic Ca

A

BRCA1/BRCA2 - proteins

TSG

18
Q

Melanoma

Pancreatic Ca

A

CDKN2A - p16, blocks G1 –> S phase

TSG

19
Q

Colon Ca

A

DCC - Deleted in colon cancer

TSG

20
Q

Pancreatic Ca

A

SMAD4 (DPC4) - Deleted in pancreatin Ca

TSG

21
Q

MEN1

22
Q

Neurofibromatosis type 1

A

NF1 - Neurofibromin (Ras GTPase activating protein)

TSG

23
Q

Neurofibromatosis type 2

A

NF2 - Merlin (schwannomin) protein

TSG

24
Q

Prostate Ca
Breast Ca
Endometrial Ca

A

PTEN - Negative regulator of PI3k/AKT pathway

TSG

25
Q

Retinoblastoma

Osteosarcoma

A

Rb - Inhibits E2F; Blocks G1 –> S phase

TSG

26
Q

Most human Ca
Li-fraumeni Syndrome
SBLA Ca Syndrome: Sarcoma, Breast, Leukemia, Adrenal gland

A

TP53 - activates has p21; blocks G1 –> S phase

TSG

27
Q

Tuberous sclerosis

A

TSC1 - Hamartin protein
TSC2- Tuberin protein
(TSG)

28
Q

von-Hippel-Lindau

A

VHL - inhibits hypoxia-inducible factor 1a

TSG

29
Q

Wilms Tumor

A

WT1 - Urogenital development transcription factor

TSG

30
Q

Lynch Syndrome can cause?

A

Colon Ca
Endometrial Ca
Ovarian Ca
Skin Ca

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