Oncogenes & Tumor supressor genes Flashcards
Oncogenes
1-hit gain of function (1 allele)
Tumor supressor genes
2-hit loss of function (2 alleles)
Lynch Syndrome
MSH2
MLH1
Lung AdenoCa
ALK - Receptor tyrosine kinase
ONCO
CML
ALL
BCR-ABL - Non receptor TK
ONCO
Follicular and Diffuse Large B cell lymphoma
BCL-2 - Antiapoptotic
ONCO
Melanoma
Non-Hodgkin Lymphoma
Papillary thyroid Ca
Hairy cell Leukemia
BRAF - Serine/threonine kinase
ONCO
GI stromal tumor (GIST)
c-KIT - Cytokine receptor (Stem cell GF)
ONCO
Burkitt Lymphoma
c-MYC - transcription factor (nuclear regulator)
t(8;14)
(ONCO)
Breast and Gastric Ca
HER2/neu (c-erb82) - Receptor tyrosine kinase (epidermal growth factor receptor)
(ONCO)
Chronic myeloproliferative disorders
JAK2 - Tyrosine kinase
ONCO
Colon Ca
Lung Ca
Pancreatic Ca
KRAS - GTPase binding protein (point mutation)
ONCO
Lung Tumor
L-myc - transcription factor
ONCO
Neuroblastoma
N-myc -transcription factor
ONCO
MEN 2A
MEN 2B
Papillary thyroid Ca
Pheochromocytoma
RET - receptor TK
ONCO