Peripheral Nerve Flashcards
What is the genetic cause of Charcot-Marie-Tooth syndrome?
mutation of peripheral myelin protein 22
What is seen histologically with Charcot-Marie-Tooth syndrome?
onion bulb appearance of nerves
What is the symptomolgy progression of Charcot-Marie-Tooth syndrome?
Distal muscle weakness with atrophy starting in the legs and often develop lower extremity deformities
(toe walking, foot eversion, hammertoes)
What is Guillain-Barre syndrome?
acute inflammatory demyelinating polyneuropathy. that results in ascending weakness, paralysis, and hyporeflexia ± sensory or autonomic involvement
Forty percent of GBS patients are seropositive for __________.
Campylobacter Jejuni
How long does it take to recover from GBS?
1-3 months (depends on remyelination)
What is seen in nerve conduction studies in GBS?
delay of F waves
What is seen in CSF in GBS?
elevated protein without pleocytosis
What is the treatment of GBS?
plasma exchange; no role for steroids
What is Chonic Inflammatory Demyelinating Polyneuropathy?
chronic form of GBS
What is ALS?
Degeneration of anterior horn motor neurons resulting in a mixed upper and lower motor neuron disease:
- Affects motor system (extremity weakness, bulbar symptoms, diaphragm, etc.) with ocular and
bladder sparing. There are no sensory symptoms. - Tongue atrophy and fasciculations are classic
What is Martin-Gruber anastamosis?
median to ulnar nerve crossover in the forearm; important to identify to prevent confusion with NCV
What causes the compression in thoracic outlet syndrome?
anterior and medial scalene muscles?
What part of the brachial plexus is affected in neurogenic thoracic outlet syndrome?
lower trunk
What are visual evoked potentials?
potentials evoked from the occipital lobe from retinal stimulation
