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Citow - Neurology > Multiple Sclerosis and Variants > Flashcards

Multiple Sclerosis and Variants Flashcards

1
Q

What HLA type is associated with MS?

A

HLA-DR2

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2
Q

What causes an oligoclonal band pattern in MS?

A

elevated IgG in the CSF

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3
Q

What is Schilder’s disease?

A

massive demyelination in children and adolescents, affecting bilateral hemispheres, brainstem, and cerebellum

Malignant course

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4
Q

What is Balo’s concentric sclerosis?

A

alternating spared and damaged white matter
progressing in concentric ringlike fashion from the ventricles outward

typically fatal

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5
Q

What is the pathophysiology of neuromyelitis optica (Devic’s disease)?

A

IgG autoantibodies versus aquaporin 4 on astrocytes

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6
Q

What are the imaging findings for neuromyelitis optica?

A

MRI shows optic nerve/chiasm enhancement and/or spinal cord lesion affecting more than three
segments in length

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Citow - Neurology (25 decks)

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