Perception of Pain Flashcards
vanilloid receptors respond to what type of stimulus
heat
protons
capsaicins
anandamide
what is the gate control theory
innocuous fibres inhibit nociceptive fibres
how does the gate control theory work (mechanism of action)
activation of the A-alpha/beta fibres also activates an interneuron within the spinal cord –> interneuron release inhibitory peptides and binds to the terminal of the A-delta/C fibres –> decreased: action potential –> signal to brain
what is the other pain modulation
descending controls: from the periaquductal grey and nucleus raphe magnus
what is hyperalgesia
increased response from a mild stimulus
what is allodynia
inappropriate response from a stimulus e.g. light brushing causes pain
examples of some basic NSAIDs
aspirin and ibuprofen
main features of NSAIDs
antipiretic, analgesic and non-inflammatory
what is antipiretic mean
reduce fever
what does cyclo-oxygenase do
convert arachidonic acid to prostaglandins
how do prostaglandins induce pain
sensitise nociceptors to bradykinin
what are the two main analgesic
NSAIDs and opioids
