Affective Disorders – depression Flashcards
function of reserpine
inhibits vestibular monoamine transporter (VMAT), stopping the release of neurotransmitters to activate downstream receptors
what will happen if there is an increase in MAOI
there will be less oxidation of neurotransmitter (NA, DA and 5-HT), leading to more of these neurotransmitter in the synaptic cleft
where would you mostly find MAO-A
gut, liver, placenta and skin
where would you mostly find MAO-B
brain, platelets and lymphocytes
name an irreversible MAOI
iproniazid
which type of MAO selectivity (A or B) is mostly used for a anitparkinson
B
what was the first tricyclic antidepressant
imipramine
what other types of receptors do tricyclic antidepressants work on
a1 and a2 adrenergic receptors,
muscarinic receptors
h1 histamine receptors1
some side effects of tricyclic antidepressants
- drowsiness
- blurred vision, dry eyes, constipation
- enable to control bp (hypotension)
name a serotonin selective transporter inhibitor
fluoxetine
what is the difference between TCAs and SSRIs
TCAs work by blocking the reuptake of neurotransmitters, but they also bind to other receptors, causing side effects.
SSRIs are more specific and only affect serotonin reuptake.
give examples of some atypical antidepressants
bupropion
veltafaxine
what was the mechanism of action of lithium, for the treatment of depression
blocking the release of calcium
examples of some psychedelics
ketamine
MDMA
LSD
psilocybin (mushrooms)
