Monoamines & Schizophrenia Flashcards
negative symptoms of schizophrenia
amotivation
social withdrawal
anhedonia
flat affect
what is anhedonia
Anhedonia is the inability to experience joy or pleasure
two drugs that were used in old schizophrenic institutes
chloral hydrate and paraldehyde
back then what was reserpine used for
to help with psychotic sympotoms
antipsychotic drugs mostly work on what type of receptors
D2 (dopamine)
are antipsychotic drugs are antagonist or agonist drugs
antagonist
examples of first gen antipsychotic drugs
chlorpromazine
flupentixol
haloperidol
what are the second generation of antipsychotic drugs
clozapine
olanzapine
risperidone
what is the third generation of antipsychotic drug
aripiprazole
how do first gen AP drugs affect the mesolimbic pathway
AP drugs decrease the over activation of the mesolimbic pathway - causing decrease in positive symptoms
how do first gen AP drugs affect the mesocortical pathway
decrease the activation of the pathway and therefore leading to the increase in negative symptoms
examples of negative symptoms
apathy
anhedonia
decrease in social interactions
problems in cognitive function
how does first gen AP drugs affect the tuberoinfundibular pathway
drug stops dopamine from reducing prolactin secretion, leading to hyperprolactiemia
how does first gen AP drugs affect the nigrostriatal pathway
inhibits the pathway, causing extrapyramidal symptoms
effects of second gen AP drugs on the mesolimbic pathway
decrease in positive symptoms
effects of second gen AP drugs on nigrostriatal and tuberoinfundibluar pathway
N: blocks serotonin receptors, increasing dopamine release = decrease in EPS
T: inhibits pathway = decrease in hyperporlactinemia
effects of second gen AP drugs on the mesocortical pathway
blocks serotonin 2C receptors in prefrontal cortex, increased release of DA and NE = decrease in negative and cognitive symptoms
first and second gen AP drugs have what effect on M1 ACh receptors
antagonistic effect -
dry mouth
constipation
blurred vision
cognitive slowing
first and second gen AP drugs have what effect on H1 Histamine receptors
antagonistic effect -
drowsiness
weight gain
first and second gen AP drugs have what effect on a1 adrenergic receptor
antagonistic effect -
orthostatic hypotension decrease in ability to manage BP)
