Barbiturates & Benzodiazepines Flashcards
what were the two compounds that make barbituates
Malonic acid and urea
what is the pka for weaker acids of barbituates
8
a weaker acid from babribuates that is fast acting
thiopentone
what does anticonvulsant mean
medication used to prevent seizures by controlling abnormal electrical activity in the brain
how are benzodiazepines identified in name
drugs ending with -azepam
example of long-acting benzodiazepines
diazepam
what are a selective agonist and antagonist of GABA A receptors
agonist: muscimol
antagonist: bicuculline
what are selective agonist and antagonist of GABA B receptors
agonist: baclofen
antagonist: saclofen
what is an allosteric modulator
a drug that can change the receptor function
how many different types of subunits does alpha subunit have
6
what effect does benzodiazepines have on GABA A receptors
bind to receptors to modulate how often the channel opens (more frequent)
what effect does barbiturates have on GABA A receptors
binds to the receptors to modulate how long the channel stays open for (longer)
what is propofol mainly used for
anaesthetic agent
