Peptic Ulcer Drugs

Question 1

Triple therapy

Answer 1

Omeprexole
Metronidazole/amoxicillin
Clarythromycin

Question 2

Duration of triple therapy

Answer 2

10-14days

Question 3

Quadruple therapy

Answer 3

Bismuth subsalicyclate
Metronidazole
Tetracycline
PPI (omeprexole)

Question 4

H2 blockers

Answer 4

Ronitidine
Famotidine
Cimetidine
Nizatidine

Question 5

Stress ulcers emergency

Answer 5

H2 blockers IV

Question 6

Adverse effect of Cimetidine

Answer 6

Inhibites p450 enzymes
Crosses placenta
Antiandrogenic (gynacomastia)

Question 7

Most potent H2 blocker

Answer 7

Famotidine

Question 8

H2 blocker to be eliminated by kidney

Answer 8

Nizatidine

Question 9

Adverse effects of H2 blockers

Answer 9

Headache
Myalgia
Dizziness
Iv administration causes hallucinations and confusion

Question 10

Proton pump inhibitors

Answer 10

Omeprezole
Iansoprezole
Rabeprezole
Esomeprezole

Question 11

Site of action of PPI

Answer 11

Parietal cell canalicuili

Question 12

Zollinger ellison syndrome

Answer 12

PPI

Dicyclomine

Question 13

Duodenal ulcers

Answer 13

PPI

Question 14

Nsaid ulcer

Answer 14

ppi

Question 15

Esophigitis

Answer 15

PPI

Question 16

When is PPI taken

Answer 16

30mins before largest meal

Question 17

Adverse effects of PPI

Answer 17

Hydrochloridia
Hypergastrinemia (carcinoid tumors)
B12 def.
Colitis
diarrhea
Hypocalcemia

Question 18

Prostaglandins

Answer 18

Misoprostol (PGE1)

Question 19

Prophylactic therapy in NSAID users

Answer 19

Misoprostol

Question 20

Contraindicated in pregnancy due to contractions

Answer 20

Misoprostol

Question 21

AE of misoprostol

Answer 21

Diarrhea nausea

Question 22

Antimuscuranics

Answer 22

Diacyclomine

Question 23

AE of Diacyclomine

Answer 23

Dry mouth
Arrythmia
Constipation

Question 24

Antacids

Answer 24

Weak bases

Salts of alimunium and magnesium

Question 25

Sodium bicarbonate

Answer 25

Metabolic alkalosis

Question 26

Last line therapy for duodenal ulcers

Answer 26

Antacids

Question 27

Aluminium salts

Answer 27

Constipation

Question 28

Magnesium salts

Answer 28

Diarrhea

Question 29

Contraindications of sodium salts

Answer 29

HT HF RF

Question 30

Mucosal protective agents

Answer 30

Sucralfate | Bismuth subsalicyclate

Question 31

Sucralfate

Answer 31

Aluminium hydroxide+ sulfated sucrose

Question 32

Sucralfate

Answer 32

Aluminium hydroxide+ sulfated sucrose

Question 33

MOA of sucralfate

Answer 33

Binds to +vely charged proteins and forms a complex gel with epithelial cells that acts as a barrier against HCl Increases PG and HCO3

Question 34

Why is sucralfacte not given with antacids and H2blockers

Answer 34

It requires low ph

Question 35

Bismuth subsalicyclate MOA

Answer 35

Inhibits pepsin and increases mucus | Interacts with glycoprtein in necrotic tissue to preserve ulcer

Question 36

PPIs given IV

Answer 36

Esomeprazole, lansoprazole and pantoprezole