Laxatives Flashcards
6 classes
- Irritants and stimulants
- Bulk laxative
- Saline and osmotic laxative
- Stool softners
- Lubricants
- Cl channel activator
Irritants and stimulants
Senna
biacodyl
castor oil
Senna
- contains sinnosides (anthraquinone glycoside)
- evacuates bowel in 8-10hrs
- treats opiod induced constipation with docusate
Bisacodyl
- stimulant of colon
- not taken with antacids/ppi to prevtn premature dissolving of enteric coat
- causes cramps and ATONIC COLON
Castor oil
- converted to ricinoleic acid which causes irration of gut
2. contraindicated in pregancy
Bulk laxatives
methylcullulose
psyllium seeds
bran
Bulk laxatives MOA
Hydrophillic colloids that form gels in intestine which causes water retentuon and distenstion to increase perilstalsis
bulk laxatives are contraindicated in
bed ridden pts
Saline and osmotic laxatives
Saline cathrartics (salts of magnesium and sodium)
Polyethlene glycol solutuons
lactulose
MOA of saline cathartics
non absorb able salts that hold water in intestine that distends bwoel for defecation
Used for radiological exam prep
polyethylene glycol solution
causes least cramply
Polyethlyene gycol solution
Lactulose
osmoatic laxative
Stool softners
Docusate ssodium, calcium and potassium
Lubricants
Mineral oil and glycerin suppositeries
taken orally upright