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Biochemistry > Pentose phosphate pathway > Flashcards

Pentose phosphate pathway Flashcards

1
Q

Different name for the pentose phosphate pathway

A

Shunt pathway

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2
Q

What is the pentose phosphate important for the production of?

A

Ribose
NADPH

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3
Q

What is the pentose phosphate pathway a pathway of?

A

Glucose-6-phosphate

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4
Q

What does the pentose pathway yield?

A

Pentoses and reduced cofactors

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5
Q

What are the pentoses produced in pentose phosphate pathway used for?

A

Nucleotide synthesis

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6
Q

What are the reduced cofactor produced in pentose phosphate pathway used for?

A

Biosynthesis of fatty acids, sterols and other compounds

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7
Q

What is the metabolism of glucose-6-phosphate either through glycolytic pathway or pentose phosphate pathway dependant on?

A

Metabolic demands

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8
Q

Are red blood cells sensitive to reactive oxygen species?

A

Yes because they don’t have mitochondria

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9
Q

What are the reactants in the pentose phosphate pathway?

A

Glucose-6-phosphate
NADP+
H2O

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10
Q

Products of the pentose phosphate pathway

A

Ribose-5-phosphate
NADPH
H2
CO2

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11
Q

What can NADPH deficiency lead to?

A

Haemolytic anemia

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12
Q

What does Glucose-6-phosphate deficiency give more resistance to malaria?

A

Because it leads to NADPH deficiency which is needed for malaria

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13
Q

2 phases of the pentose phosphate pathway

A

Oxidative phase
Non oxidative phase

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14
Q

What does the oxidative pentose phosphate pathway produce?

A

NADPH and pentose phosphates

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15
Q

What is the pentose phosphate pathway required for?

A

Rapid cell growth

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16
Q

What is rapid cell growth?

A

The production of DNA, RNA and lipids

17
Q

What does ROS stand for?

A

Reactive oxygen species

18
Q

What does gluthione protect agains?

A

Reactive oxygen species

19
Q

Where do most free radicals come from?

A

Mitochondrial respiration

20
Q

What is Glutathione?

A

An antioxidant

21
Q

2 important products in the nonoxidative phase of pentose phosphate pathway

A

Fructose-6-phosphate
Glyceraldehyde 3-phosphate

22
Q

What is the main regulatory mechanism?

A

Ratio between NADPH and NADP

23
Q

Are the reactions in the Pentose phosphate pathway reversible?

A

Yes all of them

24
Q

What is the pentose phosphate pathway?

A

An alternative pathway for glucose oxidation

25
Q

What does the pentose phosphate pathway yield?

A

Pentoses for nucleotide synthesis
Reduced cofactors for biosynthesis

26
Q

What kind of enzyme is utilised when NADP+ is present?

A

A dehydrogenase

27
Q

How many carbons in Ribulose 5-phosphate?

A

5

Biochemistry (28 decks)

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