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Biochemistry > Citric acid cycle > Flashcards

Citric acid cycle Flashcards

1
Q

What happens in cellular respiration?

A

Pyrucate is oxidized to H2O and CO2

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2
Q

What is the first step of cellular respiration?

A

Production of acetyl CoA

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3
Q

Under which conditions is glucose turned into Acetyl CoA?

A

Aerobic

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4
Q

Under which conditions does the citric acid cycle happen?

A

Aerobic

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5
Q

What is the second step of the cellular respiration?

A

Oxidation of acetyl groups to CO2 in the citric acid cycle

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6
Q

What is stage 3 of cellular respiration?

A

Electron transport chain and oxidative phosphorylation

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7
Q

What is the mitochondrial pyruvate carrier (MPC)?

A

H+ coupled pyruvate specific symporter

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8
Q

Where is the mitochondrial pyruvate carrier (MPC) found?

A

Inner mitochondrial membrane

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9
Q

Why is oxygen so important?

A

To regenerate NAD

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10
Q

Where are the two NAD pools located?

A

Cytoplasm
Mitochondria

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11
Q

What does the citric acid cycle oxidizes?

A

Acetyl CoA to CO2 and H2O

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12
Q

Most important allosteric regulartor

A

ATP and ADP

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13
Q

Different name for citric acid cycle

A

Krebs cycle

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14
Q

What is the citric acid cycle a source of?

A

Biosynthetic precursor

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15
Q

What is the fuel for citric acid cycle?

A

Acetyl CoA

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16
Q

Where does the citric acid cycle take place?

A

Matrix of mitochondria

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17
Q

What I s substrate channeling?

A

The passage of intermediates from one enzyme directly to another enzyme without release

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18
Q

What allows lipoamide to move between different active sites?

A

Flexible linkage

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19
Q

How many steps does the citric acid cycle have?

A

8

20
Q

What is the first reaction of the citric acid cycle?

A

Citrate syntheses (formation of citrate)

21
Q

What does citrate synthase catalyse?

A

Condensation of acetyl CoA with oxaloacetate to form citrate

22
Q

What is the delta G of the first reaction in the citric acid cycle?

A

Very negative, pretty much irreversible

23
Q

What kind of fit does citrate synthase exhibit?

A

Induced fit

24
Q

What is the reaction intermediate of the first reaction of the citric acid cycle?

A

Citryl CoA

25
Q

Is the second reaction of the citric acid cycle endergonic or exergonic?

A

Endergonic

26
Q

Which enzyme is used in the second reaction of the citric acid cycle?

A

Aconitase

27
Q

What does aconite catalyse?

A

The reversible transformation of citrate to isocitrate

28
Q

What is the intermediate of the second reaction of the citric acid cycle?

A

Cis-aconitate

29
Q

Which enzyme catalyses the third reaction in the citric acid cycle?

A

Isocitrate dehydrogenase

30
Q

What catalysis the fourth reaction in the citric acid cycle?

A

Alpha-ketoglutarate dehydrogenase complex

31
Q

What catalyses the fifth reaction of the citric acid cycle?

A

succinylcholine CoA synthetase

32
Q

GTP + ADP <->

A

GDP + ATP

33
Q

What catalyses the conversion of GTP and ATP

A

Nucleoside diphosphate kinase

34
Q

What catalyses the sixth reaction of the citric acid cycle?

A

Succinate dehydrogenase

35
Q

What is delta G of the sixth reaction of the citric acid cycle?

A

0

36
Q

What catalyses the hydration of fumerate to L-malate?

A

Fumerase

37
Q

What enzyme catalyses the seventh reaction of the citric acid cycle?

A

Fumerase

38
Q

What enzyme catalyses the eighth reaction of the citric acid cycle?

A

Malate dehydrogenase

39
Q

What can oxaloacetate do to initiate another cycle?

A

Condense with another acetyl CoA

40
Q

What inhibits citrate synthase?

A

ATP
NADH
Citrate
Succinylcholine CoA

41
Q

What stimulates citrate synthase?

A

ADP

42
Q

What stimulates isocitrate dehydrogenase?

A

Calcium
ADP

43
Q

What inhibits isocitrate dehydrogenase?

A

ATP

44
Q

What inhibits alpha ketogluterate dehydrogenase?

A

Succinylcholine CoA
NADH

45
Q

What stimulates alpha ketogluterate dehydrogenase?

A

Calcium

Biochemistry (28 decks)

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