Pentose Phosphate Pathway

Question 0

Transketolase converts xylulose-5-phosphate and ribose-5-phosphate to ____

Answer 0

Glyceraldehyde 3-phosphate

Sedoheptulose 7-phosphate

Question 1

_____ converts ribulose-5-phosphate to ribose 5-phosphate , _____ converts ribulose-5-phosphate to xylulose-5-phosphate

Answer 1

Isomerase

Epimerase

Question 2

Transaldolase converts Glyceraldehyde 3-phosphate and

Sedoheptulose 7-phosphate to

Answer 2

Erythrose 4-phosphate

Fructose 6-phosphate

Question 3

Transketolase requires _____ as a cofactor

Answer 3

Thiamine pyrophosphate

Question 4

Transketolase transfers a ____ carbon keto fragment , transaldolase transfers a ____ carbon keto fragment

Answer 4

2 3

Question 5

NADPH, rather than NADH, is used primarily for reductive reaction in the cell because ratio of NADPH/NADP+ is much _____ than ratio of NADH/NAD+

Answer 5

Higher

Question 6

NADPH cannot be directly oxidized by ____

Answer 6

ETC

Question 7

The reduction potential of NADPH can contribute to energy needed for ____ process and a constant source of reducing power for _____

Answer 7

Bio synthetic

Detoxification reaction

Question 8

Name 3 type reactions in the Conversion of Glucose 6 phosphate to ribulose 5 phosphate

Answer 8

Oxidation
Hydrolysis
Decarboxylation

Question 9

If the cell needs nucleotide but not NADPH, the _____ phase is inhibited and ribose 6-p will be generated from glycolytic intermediate using the _____ phase

Answer 9

Oxidative

Nonoxidative

Question 10

If the cell needs NADPH but not nucleotide, the oxidative phase is _____, and ribose 5-P will be converted to ______ through nonoxidative phase

Answer 10

Activated

Glucose 6-P

Question 11

All cells require_____for reductive detoxification , and most cells require _____ for nucleotide synthesis

Answer 11

NADPH

Ribose-5-P

Question 12

The oxidative stage of PPP generates ___ NADPH for each G-6-P oxidized

Answer 12

2

Question 13

_____ is used for the reduction of oxidized glutathione.

Answer 13

NADPH

Question 14

Glutathione is necessary for the removal of _____ and ______ generated by ROS

Answer 14

H2O2

Lipid peroxide

Question 15

The glutathione defense system is compromised by _________, infection, drugs, purine glycosides of fava beans

Answer 15

Glucose 6-P dehydrogenase deficiency

Question 16

_______ are formed on the cell membrane of RBC by damage to hemoglobin due to oxidative damage, it is an aggregates of _____

Answer 16

Heinz bodies

Cross-linked hb

Question 17

The action of ROS on the cell membrane as well as mechanical stress from the lack of deformability result in_____

Answer 17

Hemolysis

Question 18

____ catalyzes first step of PPP

Answer 18

Glucose 6 phosphate dehydrogenase

Question 19

In oxidative phase of PPP, glucose-6-phosphate is oxidized to _____

Answer 19

Ribulose-5-phosphate
CO2
NADPH

Question 20

For every 3 glucose 6-phosphate that enters PPP, ___ fructose 6-P and ___ glyceraldehyde 3-P

Answer 20

2, 1