Integration Of Fuel Metabolism

Question 0

Glycogen synthase is activated by the ________ that occurs when insulin is ____ and glucagon is _____

Answer 0

Dephosphorylation
Elevated
Decreased

Question 1

In the conversion of G-6-P to glycogen, the key regulatory enzyme is _____

Answer 1

Glycogen synthase

Question 2

Glucokinase is a liver enzyme that has a High Km for ______

Answer 2

Glucose

Question 3

Glycolysis is needed for both ____ production and ___ synthesis

Answer 3

Energy

TG

Question 4

Reduced energy consumption increases level of ______ and decrease the level of ____ , slowing down citric acid cycle

Answer 4

NADH

ADP

Question 5

Increased cytosolic _____ promotes synthesis of fatty acid and cholesterol

Answer 5

Acetyl-coA

Question 6

LPL in adipose tissue has higher _____ than those in muscle, and is most active in ___ state

Answer 6

Km

Fed

Question 7

_____ stimulates the secretion of LPL from adipose tissue

Answer 7

Insulin

Question 8

The ___ tissue cannot utilize the glycerol derived from TG as it lacks ______

Answer 8

Adipose

Glycerol kinase

Question 9

In fed state, insulin increase the number of glucose transporter in _______, promoting absorption of glucose

Answer 9

Adipocyte

Question 10

The oxidation of glucose in adipocyte produces the energy and ___ for TG synthesis

Answer 10

Glycerol 3-phosphate

Question 11

High NADH/NAD+ ratio diverts oxaloacetate into ____ to exit mitochondria and participate in _____

Answer 11

Malate

Gluconeogensis

Question 12

High ____ level inhibits isocitrate dehydrogenase, leading to citrate accumulation and product inhibition of citrate synthase

Answer 12

NADH

Question 13

As blood glucose drops, insulin level ____, the number of _____ transporter in the muscle plasma membrane is reduced, leading to reduced glucose uptake

Answer 13

Decrease

Glut4

Question 14

Low level of ____ causes activation of CPTI

Answer 14

Malonyl-coA

Question 15

During fasting, as blood insulin level fall and glucagon level rise, the level of cAMP _____ in adipose cells, consequently, protein kinase A is activated and cause phosphorylation of _____

Answer 15

Increases

Hormone sensitive lipase (HSL)

Question 16

Glucokinase is a liver enzyme that has high Km for _____, because of the enzyme’s ___ affinity for glucose, the enzyme is most active in fed state.

Answer 16

Glucose

Low

Question 17

The lipoprotein triacylglycerols in chylomicron and VLDL are hydrolyzed to fatty acid and glycerol by _____

Answer 17

Lipoprotein lipase (LPL)