Metabolic Regulation

Question 0

Site of pro glucagon synthesis include

Answer 0

Alpha cell of islet of Langerhans in the pancreas

L-cells if the intestine

Question 1

Somatostatin inhibit the release of

Answer 1

Growth hormone
Insulin
Glucagon
Thyroid hormone

Question 2

Somatostatin is used in treatment of secretory neoplasm such as _____ of pituitary and associated gigantism or _____

Answer 2

GH-secreting tumor

Acromegaly

Question 3

Insulin suppress glucagon release from pancreatic a-cell through ____ function

Answer 3

Paracrine

Question 4

Counter regulatory hormone often specifically refers to hormones that oppose action of ______

Answer 4

Insulin

Question 5

Counter regulatory hormone raise blood glucose level by promoting ______, ____ , and ______

Answer 5

Glycogenolysis
Gluconeogensis
Ketogenesis

Question 6

Counter regulatory hormone that oppose the action of insulin includes ______

Answer 6

Glucagon
Growth hormone
Catecholamines
Glucocorticoid

Question 7

Glucagon promotes Glycogenolysis

Gluconeogensis Ketogenesis by generating _____ in target cell

Answer 7

cAMP

Question 8

Somatostatin (SS-14), a cyclic peptide, is produced from the _____

Answer 8

Preprosomatostatin

Question 9

Prosomatostatin (SS-28) is seen in _____ and is 7-10 times more potent than ______

Answer 9

Gut

Somatostatin (SS-14)

Question 10

Growth hormone is secreted by ____ cells in the anterior pituitary

Answer 10

Somatotroph

Question 11

____ stimulates and ______ inhibits the release of growth hormone from the anterior pituitary

Answer 11

GHRH

Somatostatin

Question 12

IGF-1 inhibits ________ release and stimulates _____ release

Answer 12

GHRH

Somatostatin

Question 13

GHRH and somatostatin is released from ______

Answer 13

Hypothalamus

Question 14

GH increases the availability of fatty acids for _____, and decreases the oxidation of ____ and ____

Answer 14

Oxidation

Glucose amino acids

Question 15

GH decreases ______ esterification in _____ tissue

Answer 15

Fatty acid

Adipose

Question 16

Free fatty acid and glycerol are released into the blood to be metabolized by the ____

Answer 16

Liver

Question 17

GH increase the sensitivity of the adipocyte to _____ action of catecholamine and decrease its sensitivity to the ____ action of insulin.

Answer 17

Lipolytic

Lipogenic

Question 18

In liver, IGF-1 increases ___ up takes and initiates cell propagation

Answer 18

Thymidine

Question 19

IGF-1 is more potent than ____ in growth promoting action

Answer 19

Insulin

Question 20

During fasting state, GH enhances hepatic _______ , leading to increased level of acetyl-coA

Answer 20

Fatty acid oxidation

Question 21

____ is the precursor for catecholamines

Answer 21

Tyrosine

Question 22

Norepinephrine is synthesized in adrenal _____ and various area of the ___ and in ____ nerve endings

Answer 22

Medulla
CNS
Adrenergic

Question 23

The major function of catecholamines is to facilitate the body to adapt to _________

Answer 23

Acute and chronic stress

Question 24

Thyroid hormone amplifies the ___ action of epinephrine and increase ____ release to liver

Answer 24

Lipolytic

Glycerol

Question 25

Thyroid hormone increase the conversion of cholesterol to ____

Answer 25

Bike salt

Question 26

Thyroid hormone increase ____ uptake by the muscle

Answer 26

Glucose

Question 27

T3 is more active than ____, T4 can be converted to T3 by ____

Answer 27

T4

Deiodination