Nitrogen Metabolism

Question 0

During transamination, amino group of an amino acid is transferred to ____, forming _____

Answer 0

A-ketoglutarate

Glutamate

Question 1

Most amino acid degradation occurs in the ______

Answer 1

Liver

Question 2

All amino acid, except _____ can participate in transamination

Answer 2

Lysine

Threonine

Question 3

Transamination reaction are catalyzed by ____, and requires ___ as coenzyme

Answer 3

Aminotransferase
Pyridoxal phosphate(PLP)

Question 4

alanine amino transferase converts alanine to ______

Answer 4

Pyruvate

Question 5

Aspartate amino transferase converts aspartate to _____

Answer 5

Oxaloacetate

Question 6

Oxidative deamination occurs in the ____

Answer 6

Mitochondria

Question 7

Glutamate dehydrogenase is inhibited by ____ and activated by ______

Answer 7

ATP GTP NADH

ADP GDP

Question 8

Glutamine is made from glutamate using the enzyme ______, the enzyme adds a ____ to glutamate

Answer 8

Glutamate synthetase

NH4+ ammonia

Question 9

Glutamine is converted back to glutamate by _____ in the liver

Answer 9

Glutaminase

Question 10

_____ converts IMP to AMP, _____ converts IMP to GMP

Answer 10

Adenylsuccinate synthetase

IMP dehydrogenase

Question 11

The base of IMP (inosine mono phosphate) is ___

Answer 11

Hypoxanthine

Question 12

Hypoxanthine + PRPP = ______

Catalyzed by ____

Answer 12

IMP

HGPRT

Question 13

Xanthine is converted to Uric acid by ____

Answer 13

Xanthine oxidase

Question 14

Endonuclease converts ___ to ____

Answer 14

Nucleus acid

Monophosphate

Question 15

___ and ____ convert mono phosphate to nucleoside

Answer 15

Phosphatase

5-nucleotidase

Question 16

____ converts guanosine to guanine

Answer 16

Purine nucleoside phosphorylase (PNP)

Question 17

_____ converts inosine to hypoxanthine

Answer 17

Purine nucleoside phosphorylase (PNP)

Question 18

In the kidney, glutamine is converted to ____ and ____ by glutaminase, in the intestine, glutamine is used for ______

Answer 18

Glutamate NH3

Energy

Question 19

In a normal healthy individual, amino acid is supplied in 3 sources:

Answer 19

Dietary protein
Glucose
Body protein

Question 20

Amino acid is depleted when its carbon skeleton is used for ____, to make body protein, its also depleted by compounds that need ___

Answer 20

Energy

Nitrogen

Question 21

Synthesis of urea occurs in 4 stages
1.
2.
3.
4. Urea cycle

Answer 21

Transamination
Oxidative deamination
Transport of ammonia

Question 22

Removal of _____ is an obligatory step in oxidative degradation of amino acids

Answer 22

Amino group

Question 23

Under starvation, urea production is ____

Answer 23

Increased

Question 24

Carbamoyl phosphate synthetase converts _______ to carbmoyl phosphate

Answer 24

Ammonia+Co2+ATP

Question 25

Carbamoyl phosphate synthetase is activated by _______, which is activated by argnine

Answer 25

N-acetylglutamate

Question 26

_____ provides nitrogen in the urea cycle

Answer 26

NH3

Aspartate