Lipid Synthesis

Question 0

Acety-coA cannot pass trough __________ but citrate can.

Answer 0

mitochondria inner membrane

Question 1

The fatty acid synthase complex resides in the _____, and therefore it utilize ______ acetyl-coA

Answer 1

Cytosol

Cystoslic

Question 2

The reciprocal regulation of ________ and _______ occurs trough changes in the intramitochondrial acetyl-coA concentration

Answer 2

Pyruvate carboxylase

Pyruvate dehydrogenase

Question 3

______ generates cytoslic acetyl-coA plus oxaloacetate

Answer 3

Citrate lyase

Question 4

The high insulin/glucagon ratio after a carbohydrate meal induces the synthesis of _____(3 enzymes)

Answer 4

Malic enzyme
Glucose-6-phosphate dehydrogenase
Citrate lyase

Question 5

______ is the rate limiting step of fatty acid synthesis

Answer 5

Acetyl-coA carboxylase

Question 6

_______ allosterically activates acetyl-coA carboxylase while ____ inhibits it

Answer 6

Citrate

Palmitoyl-coA

Question 7

In fasting state, _____ inhibits acetyl-coA through _________

Answer 7

Amp

Phosphorylation

Question 8

In fed state, increased ________ induces both acetyl-coA carboxylase and fatty acid synthase

Answer 8

Insulin/glucagon ratio

Question 9

Acetyl-Coa carboxylase converts ______ to ______

Answer 9

Acety-coA

Malonyl-coA

Question 10

Resynthesis of dietary triglyceride occurs in the ____

Answer 10

Intestine

Question 11

Fatty acid elongation occurs in the _____

Answer 11

Endoplasmic reticulum

Question 12

Elongation of fatty acid is similar to fatty acid synthesis except that fatty acyl chain is attached to ____ rather than phosphopanteteheinyl residue of ACP

Answer 12

CoA

Question 13

Desaturation of fatty acid occurs in the ___ and involve the oxidation of ___ and _____

Answer 13

ER

O2 NADH