Penicillins

Question 1

Beta-lactamase inhibitors

Answer 1

1. Calvulanic acid (+Amoxicillin)
2. Sulbactam (+Ampicillin)
3. Tazobactam (+ Piperacillin)

Question 2

Which bacteria B-lactamase inhibitors don’t cover?

Answer 2

G+ :
Mycobacterium
G- :
Pseudomonas aeruginosa
Brachyspira hyodysenteriae
Mycoplasma
Chlamydia , Rickettsia

Question 3

Monobactams

Answer 3

Excellent for G -
Primary for UTI

1. Aztreonam (parenteral)
2. Tigemonam (p.o)

Question 4

Carbapenems

Answer 4

Last resort antibiotics
IV,IM
Highly active against all important known pathogenic bacteria

1. Imipenem (+ Cilastatin) - metabolized by dihydropeptidase in the kidneys
2. Meropenem