Central And Peripheral Myorelaxants

Question 1

Central myorelaxants: List

Answer 1

CNS depressants => decrease motor activity of voluntary movments without loosing conciousnss, can potentiate anesthetics

1. Guaiphenesin - spinal blocking agent (polysynaptic)
   Anti convolutions from strychnine+ tetanus, expecorant. Can cause hemolysis
2. Baclophen- GABA-B agonist (k) , inhibits neural function, large TI
3. Carisoprodol- potentiate opiods, muscle spasm analgestic, does not work in strychnine poisoning
4. Meyhocarbamol- SC , reduces muscle hyperactivity

Question 2

Peripheral muscle relaxants: Depolarizing agents

Answer 2

Neuromascular blocking agent, NO ANALGESIA
*Used in anesthesia, intubation spasic disorders

• succhnylcholie (suxamethonium): act like Ach- depolarized (but cannot fire again) - bradycardia, hyperkalemia, inc. IO pressure, anaphylaxis , inc. BP, potentiated by neostigmine and organophosphates (ACH-E inhibitors), histamine release

Question 3

Peripheral muscle relaxants: non-depolarizing agents

Answer 3

Competitive NM blocking:
Long acting: d-tubeocuraine (H release), Gallamine (no H), pancuronium

Benzylisoquinolines:

1. ATRACURIUM (intermediate, safe for kidneys+ liver, bradycardia, ),
2. Cisatracurium (immediate , intermediate) ,
3. Mivacurium (short)

Amino steriods:

1. Rocuronium (succhnylcholine alternative, anaphylaxis, no CV+H symp)
2. Vecuronium (intermediate , CB stable, causes mydriasis in birds)