Glucocorticoids

Question 1

Active substances

Answer 1

1. Prednisolone- antinflammatory, antishock , antiallergic, immunosuppressant
2. Methylprednisolone- neural protection
3. Triamicinolone - in joint problem
4. Betametasone + Dexamethasone - more potent than cortisol
5. Beclomethasone + Fluticasone - Asthma
6. Budesonide - intestinal problems

Question 2

JAK-1

Answer 2

1.Oclacitinib - inhibit JAK-1 - IL-4,13,31 , antiallergic, antipruritic , immunosuppressant (dec. WBCs)
SE: diarrhea , vomiting, very safe!
2. Lokivetmab- only dog , molocolonal Ab against IL-31 , Antipruritic, tablet once a month0

Question 3

Pharmacological effect

Answer 3

1. Inc. glucose levels
2. Mobilization to the liver
3. muscle atrophy
4. decreased growth
5. polyuria
6. gastric ulcer (COX, use omeperazole)
7. ACTH supression

*anti-inflammatory (COX) , anti-allergic, immunosuppressant (interleukin), antishock (Dec
Capillary permeability- water stays), neuroprotective (enhancing blood supply)

Question 4

Therapuetic methods

Answer 4

Systemic usage:

1. High dose once (e.g in shock)
2. ADT (alternate day therapy)- to prevent ACTH supression
3. Long acting (not recommended) - although intra-articularly is safe