PCOS and Hirsutism Flashcards
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PCOS is the most….
….common endocrine disorder among females
Hirsutism definition
Excessive hair growth in response to androgens
PCOS is a dignosis of…
…exclusion
Textbook PCOS symptoms (3)
Ovulatory dysfunction, evidence for hirsutism, obesity
Anovulatory bleeding
Sloughing of the endometrial lining after it builds to a point where it cannot sustain itself
3 principle features of pcos (Rotterdam criteria)
1) androgen excess
2) ovulatory dysfunction
3) polycystic ovaries (not uncommon in general popuation, do not cause disease)
Most frequent cause of anovulatory infertility
PCOS
PCOS is strongly associated with
Insulin resistance
PCOS onset is…
…chronic
Sudden onset of PCOS symptoms would suggest
Cushing syndrome or adrenal or ovarian tumor
PCOS pathophysiology
Imbalance of excess LH to FSH ratio, excess androgen production, increased insulin levels
Signs of androgen overprudction in PCOS vs signs of true virilization
- Hirsutism, acne, oily skin
- Deeping of voice, male pattern baldness, clitoromegaly
Acanthosis nigricans
Discoloration of skin in skin folds, occurs when hyperinsulemia is present and thus correlates to PCOS as well
Lab workup for PCOS
- Serum hCG
- Serum prolactin
- TSH
- FSH
Metformin
Drug of choice for treatment of type II diabetes, often associated with PCOS
