Pcol 2 Exam 3

Question 1

Donezepil

Ari

Answer 1

Central choliesterase inhibitor
So more ACH in the synpase therefore improving neurotransmission and increase activation of central nicotinic receptors

Treat alzeihmer a neurodegenerative disease

AE periphery:
-Bradycardia
-Bronchoconstriction
-Increase gland secretion
-Increase urine

AE central:
Insomnia

Aricept

Question 2

Rivastigmine

Exe

Answer 2

Centrall cholinesterase inhibitor
So inhibit cholinesterase so increase ACH in the synapse –> improve neurotransmission and increase activation of post-synaptic central nicotinic receptors

Treat alzeihmer a neurodegenerative disease

AE periphery:
Bradycardia
Bronchoconstriction
Increase salivation
Increase urine

AE central:
Insomnia

Exelon

Question 3

Galantamine

Raza

Answer 3

Central cholinesterase inhibitor –> so increase ACH in the synapse therefore increase activation of post-synaptic centrall nicotinic receptors

Treat alzeihmer

Peripheral AE:
-Bradycardia
-Bronchoconstriction
-Increase urination
-Increase salivation

Central AE:
-Insomnia

Razadyne

Question 4

Memantine

Namen

Answer 4

NMDA receptor antagonist

MOA:
-Block glutamate from binding to NMDA receptors –> so prevent the death to cholinergic neurons that is caused when too much activation of AMPA and NMDA receptors
-It protects the cholinergic neurons

Thera use
-Memantine (namenda) slows the progression of the alzeihmer disease
-Is use in combo with cholinesterase inhibitors

Namenda XR

Question 5

Donanemab

DonaKi LecaLeq

Answer 5

anti-amyloid monoclonal antibody

MOA:
Bind to the amyloid plaque and clear it out from the brain preventing neuronal death
The amyloid plaques are derived because of incorrect cutting at the amyloid precursor protein

Thera use
-Treat alzeihmer

AE:
-Intracranial bleeding

Kisunla

Question 6

Lecanemab

DonaKi LecaLeq

Answer 6

Anti-amyloid monoclonal antibody

MOA:
-Bind to the amyloid plaque and will remove it from the brain preventing neuronal death
-The amyloid plaque are form because of incorrect cutting in the amyloid precursor protein

Thera use:
-Treat alzeihmer pt will take it for 3-4 months and then as needed when the symptoms return

AE:
-Intracranial bleeding

Leqembi