Pattern of neuropathic disorders

Question 1

Symmetric proximal and distal weakness with sensory loss

Answer 1

Inflammatory demyelinating polyneuropathy (GBS, CIDP)

Question 2

Symmetric distal sensory loss with or without distal weakness

Answer 2

Cryptogenic sensory polyneuropathy (CSPN)
metabolic disorders
drug, toxins
hereditary (Charcot-Marie-tooth, amyloidosis)

Question 3

Asymmetric distal weakness with sensory loss

Answer 3

Multiple nerves: vasculitis, hereditary neuropathy with liability to pressure palsies, multifocal acquired demyelinating sensory and motor neuropathy, infectious (leprosy,lyme, sarcoid, HIV)
Single nerve: compressive mono neuropathy and radiculopathy

Question 4

Asymmetric proximal and distal weakness with sensory loss

Answer 4

polyradiculopathy or plexopathy due to diabetes mellitus
Meningeal carcinomatosis or lymphomatosis

Question 5

Asymmetric distal weakness without sensory loss

Answer 5

with UMN findings: motor neuron disease
without upper motor neuron findings: progressive muscular atrophy, multifocal motor neuropathy, multifocal motor axonopathy, juvenile monomeric amyotrophy

Question 6

Symmetric sensory loss and distal areflexia with upper motor neuron findings

Answer 6

B12 deficiency

Question 7

Symmetric weakness without sensory loss

Answer 7

Proximal and distal weakness: spinal muscular atrophy
Distal weakness: hereditary motor neuropathy

Question 8

Asymmetric proprioceptive sensory loss without weakness

Answer 8

sensory neuronopathy

Question 9

Autonomic Symptoms and signs

Answer 9

Neuropathies associated with autonomic dysfunction