Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Neuro > Neuromuscular junction > Flashcards

Neuromuscular junction Flashcards

1
Q

Myasthenia gravis antibodies mediate

A

post-synaptic acetylcholine receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Lamber-Eaton antibodies mediate

A

block of the pre-synaptic calcium channels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Congenial myasthenia mechanism that affect

A

presynaptic, synaptic and postsynaptic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Myasthenia gravis clinical

A

Fatigable weakness in the ocular nerve, limb, truncal
Visual blurring, diplopia, ptosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Maneuvers in suspected myasthenia gravis

A

Sustained upgaze: ptosis, medial rectus weakness
Sustained abduction of the arms: patient can no longer hold arms up or weakness
Sustained elevation of leg while supine: can no longer hold leg up or weakness
Repeated arising from chair: fatigues after several attempts
Counting aloud: dysarthria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Differential diagnosis of Myasthenia Gravis. Lamber-Eaton myasthenic syndrome

A

Sparing ocular muscle, hyporeflexia, dry mouth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Differential diagnosis of Myasthenia Gravis. Congenital myasthenic syndrome

A

No response to immunomodulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Differential diagnosis of Myasthenia Gravis. Botulism

A

Pupillary autonomic involvement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Differential diagnosis of Myasthenia Gravis. Motor neuron disease

A

Corticoespinal or corticobulbar features, muscle cramps/fasciculations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Differential diagnosis of Myasthenia Gravis. Mitochondrial disorders

A

No fluctuation, no diplopia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Differential diagnosis of Myasthenia Gravis. Acute immune demyelinating polyneuropathy

A

No fluctuation in weakness’s sreflexia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Differential diagnosis of Myasthenia Gravis. CNS disorders

A

Sudden onset, consciousness, coordination and sensation affected, ocular weakness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Differential diagnosis of Myasthenia Gravis. Thyroid ophthalmopathy

A

Proptosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

ECG in Myasthenia gravis

A

amplified 3rd wave and low 9th wave

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Myasthenia gravis treatment

A

Anticholinesterases
Immunosuppression
Thymectomy
Corticosteroids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Lambert-Eaton myasthenic syndrome clinical

A

Weakness in proximal muscles, particularly legs
Dry mouth, constipation , erectile dysfunction
Ophthalmoplegia, ptosis, bulbar and respiratory muscle weakness are less common than in MG
Hyporeflexia

17
Q

Lambert-Easton myasthenic syndrome treatment

A

Block presynaptic K+ channels

Neuro (30 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions