Pathophys 2

Question 1

What’s the M:E ratio and in which condition is it changed?

Answer 1

Normal 2-3:1
Myeloid:erythroid Ratio defined one BONE MARROW
Changed in CML 10:1-30-1

Question 2

Diagnosis of AML methods

Answer 2

Smear: >20% blasts in peripheral and bone marrow
Immuno: CD 117,33,34,13,15
Uric acid high due to high cell turnover

Question 3

What’s the hiatus leukemicus

Which conditions is it relevant

Answer 3

Absences of promylocytes and myelocytes

In AML these cells are missing, in CML they are present

Question 4

Name the myeloproliferative neoplasmic conditions MPN

Answer 4

CML
Polycythemia Vera
Essential thrombocytemia
Idiopathic myelofibrosis

Question 5

Mutation in MPNs

Answer 5

CML: BCR-ABL

ET, IMF, PV: JAK V617F

Question 6

Steps of untreated CML

Answer 6

Chronik Phase: high mature cells
Accelerated phase: 10-20% blasts
Blast crisis: more then 20% blasts

Question 7

Difference of CML and Leukemoid reaction

Answer 7

CML/leukemoid

BCR-ABL +/-
Gapa low/high
Toxic granulation low/high
Döhle bodies no/yes