Microbiology- Fungi Basics Flashcards

1
Q

Three basic caterogies of fungi

A
  1. Yeast
  2. Mould
  3. Dimorphic (can grow into both, depending on environment. On skin turns into yeast)
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2
Q

Important cel features of fungal cells (4 plus details)

A

Cell wall: multilayered, carbohydrates, polysaccharides, proteins
Cell membrane: bilayer, glycoproteins, lipids, ergosterol
Nucleus: membrane bound
Cytosole complex: organelles, mitochondria, golgi, ribosomes, ER

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3
Q

What proteins are in the cell wall of fungi?

A
Chitin 
Glucans
Mannans 
Glucomannans
Galactomannans
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4
Q

Sterol in cell membrane? And drugs a that bind it (3)

A

Ergosterol
Nystatin
Amphotericin
Ketoconazole

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5
Q

Asexual spores (5)

A
  1. Conidia
  2. Blastospore product of budding process (yeast)
  3. Arthrospore easily carried by air
  4. Chlamydospore large thick walled spore
  5. Sporangiospore quickly formed spore
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6
Q

Conidia spore

A

Non sexual

Produced from transformation of vegetative yeast or hyphal cell

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7
Q

Blastospore

A

Asexual

Conidial formation through a budding process (yeast)

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8
Q

Arthrospore

A

Asexual
Type of segmentented spore
Very light- travels easily via air

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9
Q

Chlamydospore

A

Large thick walled produced from terminal hyphal cells

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10
Q

Sporangiospore

A

Asexual

Spore fromed within seconds

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11
Q

What are the sexual fungi spores? 4

A
  1. Ascospore (pneumocystis, candida)
  2. Basidiospore (Cryptococcus, malassezia, Trichosporon)
  3. Zygospore (Mucor, Rhizopus)
  4. Deuteromycotina (fungi imperfecti)
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12
Q

What are some laboratory diagnostics of fungal diseases

A
  1. Scrapings from skin and nails
  2. Hairs plucked from involved area
  3. Microsporum-infected hairs flouresce under woods light in dark room
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13
Q

How do we obtain Amphotericin B?

A

From Streptomyces Nodosum

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14
Q

Mechanism of action of Amphotericin B?

A
  1. Hyrdophobic interaction with ergosterol on fungi cell membrane Forming a PORE
  2. Potassium leaves Fungus causing cell death
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15
Q

Classification of Mycoses (5)

A
  1. Superficial
  2. Cutaneous
  3. Subcutaneous
  4. Systemic
  5. Oppertunistic
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16
Q

Superficial mycoses causative agents

A
  1. Malassezia furfur - Pityriasis Versicolor
  2. Exophiala werneckii - tinea nigra
  3. Trichopsporon beigelii - white piedra
  4. Piedraia hortae- black piredra
17
Q

What disease is caused by MALASSEZIA FURFUR

A

Superficial mycoses

Pityriasis Versicolor

18
Q

What disease is caused by exophiala werneckii

A

Tinea nigra

19
Q

What disease is caused by trichosporon beigelii

A

White piedra

20
Q

What disease is caused by piedraia hortae

A

Black piedra