Microbiology- Fungi Basics Flashcards
Three basic caterogies of fungi
- Yeast
- Mould
- Dimorphic (can grow into both, depending on environment. On skin turns into yeast)
Important cel features of fungal cells (4 plus details)
Cell wall: multilayered, carbohydrates, polysaccharides, proteins
Cell membrane: bilayer, glycoproteins, lipids, ergosterol
Nucleus: membrane bound
Cytosole complex: organelles, mitochondria, golgi, ribosomes, ER
What proteins are in the cell wall of fungi?
Chitin Glucans Mannans Glucomannans Galactomannans
Sterol in cell membrane? And drugs a that bind it (3)
Ergosterol
Nystatin
Amphotericin
Ketoconazole
Asexual spores (5)
- Conidia
- Blastospore product of budding process (yeast)
- Arthrospore easily carried by air
- Chlamydospore large thick walled spore
- Sporangiospore quickly formed spore
Conidia spore
Non sexual
Produced from transformation of vegetative yeast or hyphal cell
Blastospore
Asexual
Conidial formation through a budding process (yeast)
Arthrospore
Asexual
Type of segmentented spore
Very light- travels easily via air
Chlamydospore
Large thick walled produced from terminal hyphal cells
Sporangiospore
Asexual
Spore fromed within seconds
What are the sexual fungi spores? 4
- Ascospore (pneumocystis, candida)
- Basidiospore (Cryptococcus, malassezia, Trichosporon)
- Zygospore (Mucor, Rhizopus)
- Deuteromycotina (fungi imperfecti)
What are some laboratory diagnostics of fungal diseases
- Scrapings from skin and nails
- Hairs plucked from involved area
- Microsporum-infected hairs flouresce under woods light in dark room
How do we obtain Amphotericin B?
From Streptomyces Nodosum
Mechanism of action of Amphotericin B?
- Hyrdophobic interaction with ergosterol on fungi cell membrane Forming a PORE
- Potassium leaves Fungus causing cell death
Classification of Mycoses (5)
- Superficial
- Cutaneous
- Subcutaneous
- Systemic
- Oppertunistic