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Parasites micro justus Flashcards

1
Q

characteristics of entAmoeba histolytica

A

trophozoite

cyst: 1-4 nuclei

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2
Q

transmission of Entamoeba hsitolytica

A

fecal oral

oral anal

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3
Q

Pathogenese of Entamoeba hsitolytica

A
  1. cyst ingestion
  2. reaches stomach and forms trophozoite
  3. replicates
  4. attaches to hot cell via GalNac
  5. local necrosis via cytotoxins
  6. invades intestine walls and eats RBCs
  7. dissemination to secondary organs (liver and lung)
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4
Q

how does entamoeba hytolitcia attache to host cell?

A

GalNac addhesion protein

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5
Q

virulence factors of Entamoeba histolytica

A
  1. GalNac
  2. Cystine kinase (cytolysis)
  3. Pholspholipase A (cystolysis)
  4. collagensase
  5. hyaluronidase
  6. elastase
  7. RNase
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6
Q

diseases caused by Entamoeba Histolytica

A
  1. intestinal amebiasis

2. extra intestinal amebiasis

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7
Q

what is intestinal amebiasis?

A 
amebiasis dysentery:
invasive inflammatory diarrhea 
ulcerations 
bloody 
pus
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8
Q

what are the extra intestinal manifestations of Entamoeba histolytica?

A

access formation in right liver lobe

ulcers that can brake and casue peritonitis

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9
Q

diagnosis if Entamoeba histoltitca?

A
  1. fecal antigen test O&P
  2. ELSIA
  3. flask shaped ulcers in colon
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10
Q

treatment of Entamoeba

A

METROnidazole
paromoMYCINE
idoloquinol (Queen idol)

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11
Q

differente between Entamoeba Histolytia and Coli?

A

Coli: part of normal flora, often confused as Hsitolytica on O&P, has MORE Nuceli usually, doesn’t ingest RBC!

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12
Q

characteristic structure of Giardia trophozoite?

A
  1. kite shaped
  2. bi nucleated
  3. 4 flagella
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13
Q

transmission of Giardia lambilia and intestinalis

A 
fecal oral (bad water)
oral anal sex
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14
Q

pathogeneiss of Giardia lambilia and intestinalis

A
  1. ingestion of cysts (min. 10-25)
  2. arrives in duodenum
  3. Tunis in to trophozoite
  4. multiplicates
  5. attachment to duodenal wall non invasive via sucking disk
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15
Q

how many cysts needed to infection of Giardia lambilia and intestinalis?

A

MIN. 10-25 which is not many…. very infective

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16
Q

disease caused b Giardia lambilia and intestinalis

A

50% asymptomatic
-foulsmelling diarrhea
stetorrhea
malabsorption of vitamins

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17
Q

diagnosis of Giardia lambilia and intestinalis

A

O&P test

elisa

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18
Q

Treatment of Giardia lamblia and intestinalis?

A

metronidazole

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19
Q

what are the human pathogens of Cryptosporodium spp.?

A

C. Parvum

C. Hominis

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20
Q

what is the infective from of Crypotsporodium?

A

sporozoite

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21
Q

transmission of cryptosporidium?

A

fecal oral

oral anal

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22
Q

life cycle of Cryptosporodium

A
  1. sporocytesare ingested
  2. sporozites will attach to intestinal surface and will mature
  3. sexual development= fertilization of oocyte
  4. oocyst can mature in intestine or be excreted
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23
Q

diseases caused by Cryptosporodium ssp

A

asymptomatic in immunodeficiency sufficient patients

severe watery diarrhea in AIDS

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24
Q

special stain to diagnose Cryptosporodium?

A

acid fast!!!

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25
characteristics of naegleria flowleri
1. amoeba 2. trophozoite (infective from) 3. cysts
26
where is naegleria floweri around in?
in fresh water
27
what do we associate with naegleria floweri infection?
water sport swimming in lakes contaminated contact lenses
28
path of enters of naegleria floweri?
enter CNS via cribriform plate
29
disease caused by naegleria floweri?
PAM= primary amoeba meningoencephalitis | rapidly progressive death in 4-5 days.
30
what is PAM?
caused by naegleria floweri rapbidly progressive disease death in 4-5 days memnigoencephalitis
31
treatment of Naegleria floweri?
Amphotericin B
32
characteristics of Toxoplasma gondii
1. sporozoa 2. forms: cyst, sporozoite, tachyzoite, bradyzoite 3. defintie host: cats 4. intermedeiate hsot: humans
33
which forms ca toxoplasma gondii be in?
cysts sporozoite tachyzoite bradyzoite
34
modes of transmission of toxoplasma gondii
1. fecal oral (cat feces cysts) 2. under cooked meat (cysts) 3. torchesssss
35
where does the sexual reporduction of T.gondii takes place?
cats intestine
36
pathogenies of t.Gondii
oocyte is being released in feces takes 3-4 days to mature in to infective cysts ingested by human sporozoites infects human cell develops in to tachyzoites (fast replication) delivered to guise where is develops into bradyzoites (slow replication= chronic)
37
order of t. Gandhi forms:
1. oocyst 2. sporozoites 3. tachyzoites 4. bradyzoites
38
diseases caused by Toxoplasma
toxoplasmosis
39
how does toxoplasmosis represent in healthy individuals?
asymtomatic lymphadenoapthy reseblmes monoucleosis
40
how does toxoplasmosis represent in chidden?
1. intrscrsnial calcifications 2. hydrocephalus 3. chorioretinits 4. deafness
41
effect of toxoplasmosis in immunocompromised ppl?
diffused encephalopathy | meningitoencephalopahty
42
what is the vector for trypanosome Brucei?
tsetse fly
43
what disease does trypanosome Bruce cause?
sleeping sickness
44
life cycle of trypanosoma?
infects would due to fly bite travels in blood until LN resporduces in csf and lymph reuptake by fly to finish growth
45
what is the Winterbottoms sign? which disease?
posterior cervial lympnode enlargement caused by tryposoma Brucei in sleeping sickness
46
explain sleeping sicknes
incubation time a few days to weeks 1. sign: ulcers at site of bite 2. cervial and axially lymphadenopathy 3. fever chills 4. chronically involves CNS and causes coma
47
how Does entamoeba move forward?
with its pseudopodia feet prcesses
48
how do protozoa ingest foot?
vie the cytostome (mouth)
49
which organisms does Metronidazole kill?
flagellated bugs: 1. entamoeba 2. gairdia lamblia 3. trichomonas vaginals
50
cryptosporidium ssp name some
1. C. parvum | 2. C. hominis
51
characteristics of trypanosoma Cruz?
flagellated in latin america reservoir cats and dogs
52
transmission of tramponosoma cruzi
vector borene: reduviid bugs feces
53
pathogenesis of trypanosoma cruzi
``` reduviid bites patient deposits feces in wound patients scratches which helps process migrates to different tissues destroyed hot cells ```
54
disease caused by trypanosoma cruzi
Chagas disease
55
what is chugs disease?
acute from severe in kids | chronic form: causes dilated myocardiopathy, megacolon, mega oesophagus
56
diagnosis if trypanosoma cruzi?
1. blood smear for acute form | 2. biopsy and geology for chronic
57
does leishmania ssp circle in blood?
no it doesnt
58
where doe leishmania stay?
as amastigotes in macrophages
59
what is the vector for leishmania ssp?
sand flys
60
classical characteristics of leishmania?
``` flagellates obligate intracellular (amastigotes in Macrophages) ```
61
name a few specials of leishmania?
1. L. tropica 2. L. braziliensis 3. L. donovoni
62
diseases caused by leishmania:
1. cautious leishmaniasis 2. mucocutanoues leichmansisasis 3. visceral leichmansiisas
63
what is cutaneous leishmaniasis?
caused by L. tropica | ulcerations of the skin
64
what is mucocutenous leishmanisiasis
caused by l. braziliensis disfiguration of face death if untreated
65
what is visceral leishmaniasis?
``` asked by L. donovoni Kala azar scattered black spots fever chills invasion of liver, spleen and bone marrow causes pancytopenia hepatosplenomegaly ```
66
diagnosis of leishmania?
take a clinical sample | tissue biopsy
67
What is the romana sign?
Shown in trypanosoma Cruzi | Edema around the eyes
68
What is the winter bottom sign?
Caused by trypanomaoma brucei | Cervical lymph ode enlargement

Stuff Thats Would Be Cool To Remember (20 decks)

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