Pathology - Vaginal/Cervical Flashcards
Incidence of GYN cancer high to low?
in the US: endometrial > ovarian > cervical
cervical cancer is more common worldwide due to lack of screening or HPV vaccination.
Prognosis of GYN cancer from worst to best?
ovarian > endometrial > cervical
SCC of Vagina happens when?
Usually 2° to cervical SCC; 1° vaginal carcinoma rare.
What affects women who had exposure to DES in utero?
Clear Cell Adenocarcinoma of the Vagina
Who gets Sarcoma botryoides?
girls less than 4 years old, grape like mass coming out of vagina
Histo of Sarcoma Botyroides?
spindle-shaped cells; desmin ⊕
How does Sarcoma Botyroides present?
clear, grape-like, polypoid mass emerging from vagina.
Where does Cervical Dysplasia and CIS occur?
begins at basal layer of squamocolumnar junction (transformation zone) and extends outward.
How is Cervical Dysplasia classified?
CIN 1, 2, 3 (severe dysplasia or carcinoma in situ), depending on extent of dysplasia.
What infection is Cervical Dysplasia/CIS associated with?
Associated with HPV 16 and HPV 18
How does Cervical Dysplasia/CIS present?
Typically asymptomatic (detected with Pap smear) or presents as postcoital vaginal bleeding
risk factors for Cervical Dysplasia/CIS? What is biggest risk factor?
multiple sexual partners (#1), smoking, starting sexual intercourse at young age, HIV infection
Invasive Cervical Carcinoma is typically what type of cancer?
squamous cell carcinoma
What is the Pap Smear for?
Pap smear can catch cervical dysplasia (koilocytes) before it progresses to invasive carcinoma
Hallmark of cervical cancer histo?
koilocytes
