Pathology - Hydatidiform Moles Flashcards
What is a Hydatidiform Mole?
abnormal conception characterized by swollen and edematous villi with proliferation of trophoblasts
What is abnormal about uterus and b-hCG in a mole?
Uterus expands as if a normal pregnancy is present, but the uterus is much larger and B-hCG much higher than expected for date of gestation
When do you see a Hydatidiform mole during pregnancy? How does it present?
second trimester as a passage of grape-like masses through vaginal canal
How is a mole diagnosed with prenatal care?
diagnosed by ultrasound during early first trimester
What is seen on Ultrasound?
fetal heart sounds are absent, SNOWSTORM appearance
Treatment of a Hydatidiform mole?
suction curettage
Why must there be B-hCG monitoring after treatment?
ensure adequate mole removal and to screen for developing choriocarcinoma
Which choriocarcinoma responds well to chemo and which does not?
arising from gestational pathway respond well to chemo
germ cell pathway (sporadic) do not respond well
Genetics of a Partial mole? how many chromosomes?
normal ovum fertilized by two sperm (or one sperm that duplicates chromosomes); 69 chromosomes
Genetics of a complete mole? how many chromosomes?
empty ovum fertilized by two sperm (or one sperm that duplicates chromosomes); 46 chromosomes
Which mole is fetal tissue present and absent?
Partial - present
Complete - absent
Which mole has hydropic villi (villous edema)?
Partial - some normal and some hydropic villi
Complete - all hydropic villi
Which mole has focal proliferation present around hydropic villi?
Partial Mole
Which mole has diffuse circumferential proliferation around hydropic villi?
Complete Mole
Which mole has risk for choriocarcinoma?
Complete mole
