Pathology - Benign Ovarian Neoplasms Flashcards
Most common adnexal mass in women > 55 years old?
Ovarian Neoplasm
Majority of malignant tumors are derived from what?
epithelial in origin
Risk for Ovarian Cancer increases with what? (4)
advanced age, infertility, endometriosis, PCOS
What three genetic predispositions lead to Ovarian Cancer?
BRCA-1 or BRCA-2 mutation
Lynch syndrome
strong family history
what decreases risk of ovarian cancer? (4)
previous pregnancy, history of breastfeeding, OCPs, tubal ligation
Ovarian cancer presents how?
adnexal mass, abdominal distension, bowel obstruction, pleural effusion.
What do you use to monitor response to therapy/relapse
CA 125 levels (not good for screening).
Most common ovarian neoplasm?
Serous Cystadenoma
What ovarian cancer is lined with fallopian tube–like epithelium. often bilateral
Serous Cystadenoma
What ovarian cancer is Multiloculated, large. Lined by mucus-secreting epithelium
Mutinous Cystadenoma
What ovarian cancer is Endometriosis (ectopic endometrial tissue) within ovary with cyst formation.
Endometrioma
What ovarian cancer presents with pelvic pain, dysmenorrhea, dyspareunia; symptoms may vary with menstrual cycle.
Endometrioma
What does the ovary look like in Endometrioma?
“Chocolate cyst”— endometrioma lled with dark, reddish-brown blood.
most common ovarian tumor in females 10–30 years old
Mature cystic teratoma (dermoid cyst)
What Ovarian Tumor is a Cystic mass containing elements from all 3 germ layers (eg, teeth, hair, sebum)
Mature cystic teratoma (dermoid cyst)
What is a strums ovary and how does it present?
A mono dermal form of a dermoid cyst with thyroid tissue, can present with hyperthyroidism
Why can dermoid cysts be painful?
Can present with pain 2° to ovarian enlargement or torsion.
What ovarian tumor Looks like bladder. Solid tumor that is pale yellow-tan and appears encapsulated.
Brenner Tumor
What do you see on histo with a Brenner Tumor?
“Coffee bean” nuclei on H&E stain.
What does a fibroma look like on histo?
Bundles of spindle-shaped fibroblasts
What presents with a ‘pulling’ sensation in the groin?
Fibroma
What is Meigs Syndrome triad?
triad of ovarian fibroma, ascites, hydrothorax.
What benign ovarian tumor can secrete estrogen?
Thecoma
How does a Thecoma present?
Usually presents as abnormal uterine bleeding in a postmenopausal woman.
What is the analogous malignant ovarian tumor to a benign Thecoma?
Granulosa Cell Tumor (both secrete estrogen)
